Evidence map›Paper›PMID 30944149›Full record

Trial reportJournal of neurology, neurosurgery, and psychiatry2019

Multicentre, randomised controlled trial of PDSAFE, a physiotherapist-delivered fall prevention programme for people with Parkinson's.

Kim Chivers Seymour, Ruth Pickering, Lynn Rochester, Helen C Roberts, Claire Ballinger, Sophia Hulbert, Dorit Kunkel, Ioana R Marian, Carolyn Fitton, Emma McIntosh and 4 more

Open access · hybridAbstract readMulticenter StudyPragmatic Clinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurology, neurosurgery, and psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 9 pooled it
21.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 9 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Pooled it
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  6. Interventions for preventing falls in Parkinson's disease.The Cochrane database of systematic reviews · 2022
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  7. Guideline
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  10. Trial
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  20. 'It Would've Been Nice to Know About Allied Health Earlier': Insights From People With Parkinson's Disease.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Kim Chivers SeymourSchool of Health Sciences, University of Southampton, Southampton, UK.ORCID 0000-0002-0236-1913
Ruth PickeringFaculty of Medicine, University of Southampton, Southampton, UK.
Lynn RochesterInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom.
Helen C RobertsFaculty of Medicine, University of Southampton, Southampton, UK.
Claire BallingerFaculty of Medicine, University of Southampton, Southampton, UK.
Sophia HulbertSchool of Health Sciences, University of Southampton, Southampton, UK.
Dorit KunkelSchool of Health Sciences, University of Southampton, Southampton, UK.
Ioana R MarianFaculty of Medicine, University of Southampton, Southampton, UK.
Carolyn FittonSchool of Health Sciences, University of Southampton, Southampton, UK.
Emma McIntoshHEHTA, University of Glasgow, Glasgow, UK.
Victoria A GoodwinCollege of Medicine, University of Exeter, Exeter, UK.ORCID 0000-0003-3860-9607
Alice NieuwboerDepartment of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
Sarah E LambOxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.
Ann AshburnSchool of Health Sciences, University of Southampton, Southampton, UK ann@soton.ac.uk.ORCID 0000-0002-4619-5603
University of Southampton · GBFaculty (United Kingdom) · GBKU Leuven · BENewcastle University · GBUniversity of Exeter · GBUniversity of Glasgow · GBUniversity of Oxford · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

objectiveTo estimate the effect of a physiotherapist-delivered fall prevention programme for people with Parkinson's (PwP).

methodsPeople at risk of falls with confirmed Parkinson's were recruited to this multicentre, pragmatic, investigator blind, individually randomised controlled trial with prespecified subgroup analyses. 474 PwP (Hoehn and Yahr 1-4) were randomised: 238 allocated to a physiotherapy programme and 236 to control. All participants had routine care; the control group received a DVD about Parkinson's and single advice session at trial completion. The intervention group (PDSAFE) had an individually tailored, progressive home-based fall avoidance strategy training programme with balance and strengthening exercises. The primary outcome was risk of repeat falling, collected by self-report monthly diaries, 0-6 months after randomisation. Secondary outcomes included Mini-BESTest for balance, chair stand test, falls efficacy, freezing of gait, health-related quality of life (EuroQol EQ-5D), Geriatric Depression Scale, Physical Activity Scale for the Elderly and Parkinson's Disease Questionnaire, fractures and rate of near falling.

resultsAverage age is 72 years and 266 (56%) were men. By 6 months, 116 (55%) of the control group and 125 (61.5%) of the intervention group reported repeat falls (controlled OR 1.21, 95% CI 0.74 to 1.98, p=0.447). Secondary subgroup analyses suggested a different response to the intervention between moderate and severe disease severity groups. Balance, falls efficacy and chair stand time improved with near falls reduced in the intervention arm.

conclusionPDSAFE did not reduce falling in this pragmatic trial of PwP. Other functional tasks improved and reduced fall rates were apparent among those with moderate disease. TRIAL REGISTRATION NUMBER: ISRCTN48152791.

Indexed as

Physical Therapy ModalitiesAccidental FallsAgedAged, 80 and overExercise TherapyFemaleHumansMaleMiddle AgedParkinson DiseasePostural BalanceQuality of LifeResistance TrainingCognitionDisease severityFall preventionFreezing of gaitParkinson'sPhysiotherapy

Identifiers

PMID30944149
PMCPMC6585265
OpenAlexW2932221571

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.