ArticleBMJ open2019
Risk of ischaemic stroke in patients with migraine: a longitudinal follow-up study using a national sample cohort in South Korea.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis.Journal of neurology · 2022Pooled it
- The Effect of Task-Oriented Activities Training on Upper-Limb Function, Daily Activities, and Quality of Life in Chronic Stroke Patients: A Randomized Controlled Trial.International journal of environmental research and public health · 2022Trial
- Gepants in Primary Care: A Targeted Approach to Acute and Preventive Treatment of Migraine.Pain and therapy · 2025Review
- Migraine with and without aura-two distinct entities? A narrative review.The journal of headache and pain · 2025Review
- Migraine is associated with a higher risk of ischemic and hemorrhagic stroke: an analysis of theFrontiers in pain research (Lausanne, Switzerland) · 2025Article
- Association between human herpes simplex virus and severe headache or migraine among aged 20-49 years: a cross-sectional study.Frontiers in neurology · 2024Article
- Migraine and risk of premature myocardial infarction and stroke among men and women: A Danish population-based cohort study.PLoS medicine · 2023Article
- Bibliometric Analysis of Research on Migraine-Stroke Association from 2013 to 2023.Journal of pain research · 2023Article
- Review
- Increased Risk of Cardio-Cerebrovascular Diseases in Migraine Patients: A Nationwide Population-Based, Longitudinal Follow-Up Study in South Korea.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Risk for ischemic stroke and coronary heart disease associated with migraine and migraine medication among older adults.The journal of headache and pain · 2021Article
- Bidirectional association between migraine and rheumatoid arthritis: two longitudinal follow-up studies with a national sample cohort.BMJ open · 2021Article
- Sex Differences in Risk Factors for Transient Ischemic Attack in a Chinese Population.Frontiers in neurology · 2021Article
- Migraine as a Risk Factor for Peripheral Artery Occlusive Disease: A Population-Based Cohort Study.International journal of environmental research and public health · 2020Article
- Modern Contraceptive Method Utilization and Associated Factors Among Women of Reproductive Age in Gondar City, Northwest Ethiopia.Open access journal of contraception · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAccumulating evidence has supported the association between migraine and stroke, but the causative association remains unclear. We aimed to investigate the risks of different types of stroke in patients with migraine.
designA longitudinal follow-up study.
settingData collected from a national cohort between 2002 and 2013 by the South Korea Health Insurance Review and Assessment.
participantsWe extracted the data from patients with migraine (n=41 585) and 1:4 matched controls (n=1 66 340) and analysed the occurrence of ischaemic and haemorrhagic strokes. The migraine group included participants treated for migraine (International Classification of Disease-10 (ICD-10): G43)≥2 times. Haemorrhagic stroke (I60-I62) and ischaemic stroke (I63) were determined based on the admission histories. The crude and adjusted HRs were calculated using Cox proportional hazard models, and the 95% CI were determined. Subgroup analyses stratified by age and sex were also performed.
resultsHigher rates of ischaemic stroke were observed in the migraine group (2.3% [964/41,585]) than in the control group (2.0% [3294/166 340], P<0.001). The adjusted HR for ischaemic stroke was 1.18 (95% CI=1.10 to 1.26) in the migraine group (P<0.001). Compared with control subjects, participants who reported migraine with aura and migraine without aura had increased adjusted HRs of 1.44 (95% CI=1.09 to 1.89) and 1.15 (95% CI=1.06 to 1.24), respectively, for ischaemic stroke, but no increased risk of haemorrhagic stroke. In our subgroup analysis, a strong association between migraine and ischaemic stroke was observed in young patients, specifically young women. The contribution of migraine to the occurrence of ischaemic stroke was also observed in middle-aged women and old women (each P<0.05). The risk of haemorrhagic stroke did not reach statistical significance in any age group.
conclusionMigraine is associated with an increased risk of ischaemic stroke, but not haemorrhagic stroke.
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