Observational studyBMJ open2019
Focused ultrasound to diagnose HIV-associated tuberculosis (FASH) in the extremely resource-limited setting of South Sudan: a cross-sectional study.
Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating Point-of-care Ultrasound to Improve Tuberculosis Diagnosis in Children
Comparative Efficacy of Chest Ultrasound, Chest X-Ray and Computer-aided Diagnostic (CAD) for Tuberculosis Diagnosis in Low-Resource Setting: A Cross-Sectional Study From Ethiopia (CUSTB)
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Diagnostic accuracy of point-of-care ultrasound for pulmonary tuberculosis: A systematic review.PloS one · 2021Pooled it
- Abdominal ultrasound for diagnosing abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV-positive individuals.The Cochrane database of systematic reviews · 2019Pooled it
- Septic cardioembolic stroke secondary to infective endocarditis in a young patient with rheumatic heart disease: a case report.Oxford medical case reports · 2024Article
- Cardiac Tuberculosis: A Case Series from Ethiopia, Italy, and Uganda and a Literature Review.The American journal of tropical medicine and hygiene · 2024Review
- Comments and Illustrations of Ultrasound Findings in Extrapulmonary Tuberculosis Manifestations.Diagnostics (Basel, Switzerland) · 2024Review
- Article
- Comparative effectiveness of chest ultrasound, chest X-ray and computer-aided diagnostic (CAD) for tuberculosis diagnosis in low-resource setting: study protocol for a cross-sectional study from Ethiopia.Frontiers in public health · 2024Article
- Point-of-care ultrasound for tuberculosis diagnosis in children: a Médecins Sans Frontières cross-sectional study in Guinea-Bissau.BMJ open · 2023Article
- Utility of chest imaging in the diagnosis and management of patients with visceral leishmaniasis: A systematic review.SAGE open medicine · 2023Review
- Subacute Cardiac Tamponade Due to Tuberculous Pericarditis Diagnosed by Urine Lipoarabinomannan Assay in a Immunocompetent Patient in Oyam District, Uganda: A Case Report.International journal of environmental research and public health · 2022Article
- Extrapulmonary tuberculosis mortality according to clinical and point of care ultrasound features in Mozambique.Scientific reports · 2022Article
- Towards Accurate Point-of-Care Tests for Tuberculosis in Children.Pathogens (Basel, Switzerland) · 2022Review
- Task shifting for point of care ultrasound in primary healthcare in low- and middle-income countries-a systematic review.EClinicalMedicine · 2022Review
- High sensitivity of ultrasound for the diagnosis of tuberculosis in adults in South Africa: A proof-of-concept study.PLOS global public health · 2022Article
- High risk of unsuccessful treatment outcome in migrant population with tuberculosis: Data from three Italian hospitals.Frontiers in public health · 2022Article
- Focused assessment with sonography for HIV/TB.Ultrasound (Leeds, England) · 2021Article
- Common and Rare Hematological Manifestations and Adverse Drug Events during Treatment of Active TB: A State of Art.Microorganisms · 2021Review
- Hiding in plain sight: Diagnosing pleural tuberculosis using lung ultrasound.Ultrasound (Leeds, England) · 2021Article
- Population aging and trends of pulmonary tuberculosis incidence in the elderly.BMC infectious diseases · 2021Article
- New management approaches to tuberculosis in people living with HIV.Current opinion in infectious diseases · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOur cross-sectional study aimed at evaluating the diagnostic performance of Focused Assessment with Sonography for HIV-associated tuberculosis (FASH) to detect extrapulmonary tuberculosis in extremely resource-limited settings, with visceral leishmaniasis as a differential diagnosis with overlapping sonographic feature.
designCross-sectional study.
settingVoluntary Counselling and Testing Centre (VCT) of Yirol Hospital, South Sudan.
participantsFrom May to November 2017, 252 HIV-positive patients out of 624 newly admitted to VCT Centre were registered for antiretroviral treatment. According to the number of trained doctors available to practise ultrasound (US) scan, a sample of 100 patients were screened using the FASH protocol.
interventionsFollowing a full clinical examination, each patient was scanned with a portable US scanner in six different positions for pleural, pericardial, ascitic effusion, abdominal lymphadenopathy and hepatic/splenic microabscesses, according to the FASH protocol. A k39 antigen test for visceral leishmaniasis was also performed on patients with lymphadenopathy and/or splenomegaly. All demographic, clinical and HIV data, as well as FASH results and therapy adjustments, were recorded following the examination.
resultsThe FASH protocol allowed the detection of pathological US findings suggestive of tuberculosis in 27 out of the 100 patients tested. Overall, FASH results supported tuberculosis treatment indication for 16 of 21 patients, with the treatment being based exclusively on FASH findings in half of them (8 patients). The group of FASH-positive patients had a significantly higher proportion of patients with CD4 count below 0.2 x10
conclusionFASH was found to be a relevant diagnostic tool to detect signs of tuberculosis. Further research is needed to better define a patient profile suitable for investigation and also considering diagnostic accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.