ArticleBiology of sex differences2019
Inflammatory responses to dietary and surgical weight loss in male and female mice.
Article in Biology of sex differences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue.Molecular metabolism · 2025Article
- Association between dietary inflammatory index score and cardiovascular-kidney-metabolic syndrome: a cross-sectional study based on NHANES.Frontiers in nutrition · 2025Article
- Bariatric Surgery Is Associated with Lower Concentrations of Fecal Secondary Bile Acids and Their Metabolizing Microbial Enzymes: A Pilot Study.Obesity surgery · 2024Article
- The Impact of Weight Cycling on Health and Obesity.Metabolites · 2024Review
- Hepatic lipid-associated macrophages mediate the beneficial effects of bariatric surgery against MASH.Research square · 2023Article
- Article
- Sex-specific differences in metabolic outcomes after sleeve gastrectomy and intermittent fasting in obese middle-aged mice.American journal of physiology. Endocrinology and metabolism · 2022Article
- The Influence of Obesity and Weight Loss on the Bioregulation of Innate/Inflammatory Responses: Macrophages and Immunometabolism.Nutrients · 2022Review
- Weight cycling induces innate immune memory in adipose tissue macrophages.Frontiers in immunology · 2022Article
- Sex hormones regulate metainflammation in diet-induced obesity in mice.The Journal of biological chemistry · 2021Article
- Diet-dependent sex differences in the response to vertical sleeve gastrectomy.American journal of physiology. Endocrinology and metabolism · 2021Article
- Carbohydrates to Prevent and Treat Obesity in a Murine Model of Diet-Induced Obesity.Obesity facts · 2021Article
- Sex Differences of the Diabetic Heart.Frontiers in physiology · 2021Review
- Gonadal white adipose tissue-derived exosomal MiR-222 promotes obesity-associated insulin resistance.Aging · 2020Article
- Macrophages Mediate Increased CD8 T Cell Inflammation During Weight Loss in Formerly Obese Mice.Frontiers in endocrinology · 2020Article
- Sexually Dimorphic Response of Increasing Dietary Intake of High Amylose Wheat on Metabolic and Reproductive Outcomes in Male and Female Mice.Nutrients · 2019Article
- Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice.International journal of molecular sciences · 2019Article
- Sex-Specific Glucose Homeostasis and Anthropometric Responses to Sleeve Gastrectomy in Obese Patients.Nutrients · 2019Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWeight loss by surgery or lifestyle changes is strongly recommended for obese individuals to improve metabolic health, but the underlying impairments that persist from a history of obesity remain unclear. Recent investigations demonstrate a persistent inflammatory state with weight loss and bariatric surgery, but the mechanism and impact are not fully understood. Additionally, these studies have not been performed in females although women are the majority of individuals undergoing weight loss interventions.
methodsThe goal of this study was to determine the sex differences in metabolically induced inflammation after dietary weight loss (WL) or bariatric surgery. Following a 60% high-fat diet (HFD) for 12 weeks, C57Bl/6j mice underwent either a dietary switch to normal chow for WL or vertical sleeve gastrectomy (VSG) and were evaluated 8 weeks after intervention. WL effects on myelopoiesis were further evaluated with bone marrow chimeras.
resultsBoth sexes had a decrease in adiposity and total weight following WL or VSG intervention. With HFD, females had very little inflammation and no further increase with WL, but males had persistent inflammation even after WL despite metabolic improvement. Interestingly, after VSG, myeloid inflammation was increased in the livers of males and to a lesser extent in females.
conclusionsThese studies demonstrate that regardless of sex, it is critical to assess an individuals' history of obesity rather than just rely on current weight status in medical decision-making. There are long-lasting effects on tissue inflammation in both sexes especially with surgical weight loss. Dietary change is overall most effective to improve meta-inflammation in obese males on its own or in combination with surgical weight loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.