Observational studyCritical care (London, England)2019
Death after awakening from post-anoxic coma: the "Best CPC" project.
Observational study in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2025: post-resuscitation care.Intensive care medicine · 2025Guideline
- Prediction of good neurological outcome in comatose survivors of cardiac arrest: a systematic review.Intensive care medicine · 2022Pooled it
- A principal component entropy metric for assessing global synchronicity in EEG signals.Scientific reports · 2026Article
- Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable.Intensive care medicine · 2026Review
- Prognostic value of brainstem auditory evoked potentials (BAEPs) and middle latency auditory evoked potentials (MLAEPs) in unconscious patients after cardiac arrest.Critical care (London, England) · 2025Article
- Absolute blood levels and kinetics of neurofilament light (NFL) chains for neurological prognosis in comatose patients after cardiac arrest.Annals of intensive care · 2025Article
- Duration of resuscitation, regain of consciousness and histopathological severity of hypoxic-ischemic encephalopathy after cardiac arrest.Resuscitation plus · 2025Article
- Performance of the MRI lesion pattern score in predicting neurological outcome after out of hospital cardiac arrest: a retrospective cohort analysis.Critical care (London, England) · 2024Article
- Neurophysiology State Dynamics Underlying Acute Neurologic Recovery After Cardiac Arrest.Neurology · 2023Article
- Different neuroprognostication thresholds of neuron-specific enolase in shockable and non-shockable out-of-hospital cardiac arrest: a prospective multicenter observational study in Korea (the KORHN-PRO registry).Critical care (London, England) · 2023Observational
- Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest.Intensive care medicine experimental · 2023Article
- Prognostication after cardiac arrest: how EEG and evoked potentials may improve the challenge.Annals of intensive care · 2022Review
- Predicting Neurological Outcome From Electroencephalogram Dynamics in Comatose Patients After Cardiac Arrest With Deep Learning.IEEE transactions on bio-medical engineering · 2022Article
- SSEP N20 and P25 amplitudes predict poor and good neurologic outcomes after cardiac arrest.Annals of intensive care · 2022Article
- L-arginine, asymmetric and symmetric dimethylarginine for early outcome prediction in unselected cardiac arrest victims: a prospective cohort study.Internal and emergency medicine · 2022Article
- Can serum markers of brain injury predict good neurological outcome after out‑of‑hospital cardiac arrest?Intensive care medicine · 2022Article
- Article
- Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis.Intensive care medicine · 2021Review
- Predicting early recovery of consciousness after cardiac arrest supported by quantitative electroencephalography.Resuscitation · 2021Observational
- Clinical Characteristics and In-Hospital Mortality of Cardiac Arrest Survivors in Brazil: A Large Retrospective Multicenter Cohort Study.Critical care explorations · 2021Article
Corrections and comments
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Authors and funding
8 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients who recover consciousness after cardiac arrest (CA), a subsequent death from non-neurological causes may confound the assessment of long-term neurological outcome. We investigated the prevalence and causes of death after awakening (DAA) in a multicenter cohort of CA patients.
methodsObservational multicenter cohort study on patients resuscitated from CA in eight European intensive care units (ICUs) from January 2007 to December 2014. DAA during the hospital stay was extracted retrospectively from patient medical records. Demographics, comorbidities, initial CA characteristics, concomitant therapies, prognostic tests (clinical examination, electroencephalography (EEG), somatosensory evoked potentials (SSEPs)), and cause of death were identified.
resultsFrom a total 4646 CA patients, 2478 (53%) died in-hospital, of whom 196 (4.2%; ranges 0.6-13.0%) had DAA. DAA was less frequent among out-of-hospital than in-hospital CA (82/2997 [2.7%] vs. 114/1649 [6.9%]; p < 0.001). Median times from CA to awakening and from awakening to death were 2 [1-5] and 9 [3-18] days, respectively. The main causes of DAA were multiple organ failure (n = 61), cardiogenic shock (n = 61), and re-arrest (n = 26). At day 3 from admission, results from EEG (n = 56) and SSEPs (n = 60) did not indicate poor outcome.
conclusionsIn this large multicenter cohort, DAA was observed in 4.2% of non-survivors. Information on DAA is crucial since it may influence epidemiology and the design of future CA studies evaluating neuroprognostication and neuroprotection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.