ArticleMolecular brain2019
Differential sensitivity of three forms of hippocampal synaptic potentiation to depotentiation.
Article in Molecular brain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey.Hippocampus · 2026Review
- Epileptiform activity induced metaplasticity impairs bidirectional plasticity in the hippocampal CA1 synapses via GluN2B NMDA receptors.Experimental brain research · 2022Article
- Subsequent Acupuncture Reverses the Aftereffects of Intermittent Theta-Burst Stimulation.Frontiers in neural circuits · 2021Article
- Neuron type-specific expression of a mutant KRAS impairs hippocampal-dependent learning and memory.Scientific reports · 2020Article
- Depotentiation depends on IPLearning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- NMDA Receptor-Dependent Synaptic Depression in Potentiated Synapses of the Anterior Cingulate Cortex of adult Mice.Molecular painArticle
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
Abstract
Theta-burst stimulation (TBS) induces short-term potentiation (STP) plus two types of transcriptionally-independent forms of long-term potentiation (LTP), termed LTP1 and LTP2. We have compared the susceptibility of these three types of synaptic plasticity to depotentiation, induced by low frequency stimulation (LFS; 2 Hz for 10 min) at the Schaffer collateral-commissural pathway in area CA1 of adult rat hippocampal slices. In interleaved experiments, STP and LTP were induced by three episodes of either compressed or spaced TBS (cTBS or sTBS). LFS had a more pronounced effect on the LTP induced by the cTBS. One traditional interpretation of these results is a difference in the time-dependent immunity against depotentiation. We suggest an alternative explanation: LFS rapidly reverses STP to reveal a slowly developing LTP. The cTBS protocol induces LTP1 that is moderately sensitive to depotentiation. The sTBS induces an additional component of LTP (LTP2) that is resistant to depotentiation.
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Registered trials
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