Evidence map›Paper›PMID 30943912›Full record

ArticleMolecular medicine (Cambridge, Mass.)2019

Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome.

Kim R Simpfendorfer, Nancy Wang, Dedreia L Tull, David P De Souza, Amsha Nahid, Andre Mu, Dianna M Hocking, John S Pedersen, Odilia L C Wijburg, Malcolm J McConville and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Kim R SimpfendorferThe Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Nancy WangThe Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. nancyw@unimelb.edu.au.ORCID 0000-0001-7623-1858
Dedreia L TullMetabolomics Australia, Bio21 Institute, The University of Melbourne, Parkville, Australia.
David P De SouzaMetabolomics Australia, Bio21 Institute, The University of Melbourne, Parkville, Australia.
Amsha NahidMetabolomics Australia, Bio21 Institute, The University of Melbourne, Parkville, Australia.
Andre MuThe Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Dianna M HockingThe Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
John S PedersenAlfred Hospital, Monash University, Prahran, Australia.
Odilia L C WijburgThe Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Malcolm J McConvilleMetabolomics Australia, Bio21 Institute, The University of Melbourne, Parkville, Australia.
Richard A StrugnellThe Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. rastru@unimelb.edu.au.
The University of Melbourne · AUFeinstein Institute for Medical Research · USMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe polymeric immunoglobulin receptor (pIgR) maintains the integrity of epithelial barriers by transporting polymeric antibodies and antigens through the epithelial mucosa into the lumen. In this study, we examined the role of pIgR in maintaining gut barrier integrity, which is important for the normal development in mice.

methodsCohorts of pIgR

resultsWe observed that pIgR

conclusionOur data show that loss of the secretory antibody system in mice results in enhanced accumulation of inflammatory IELs in the gut, which likely reflects ongoing inflammation in reaction to gut microbiota or food antigens, leading to delayed growth in pIgR

Indexed as

MetabolomeAnimalsAntibodiesCytokinesFemaleGastrointestinal TractIntraepithelial LymphocytesMaleMice, Inbred C57BLMice, KnockoutReceptors, Polymeric ImmunoglobulinUrineAntibodiesCytokinesReceptors, Polymeric ImmunoglobulinGutInflammationPermeabilitySIgATissue resident memory T cellsUrinary biomarker

Identifiers

PMID30943912
PMCPMC6446318
OpenAlexW2945160067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.