Evidence map›Paper›PMID 30943907›Full record

ArticleBMC infectious diseases2019

Fulminant arterial vasculitis as an unusual complication of disseminated staphylococcal disease due to the emerging CC1 methicillin-susceptible Staphylococcus aureus clone: a case report.

Charles Vidal, Florence Moulin, Xavier Nassif, Louise Galmiche, Delphine Borgel, Alain Charbit, Capucine Picard, Jean-Paul Mira, Olivier Lortholary, Anne Jamet and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Charles VidalDepartment of Microbiology, Necker Enfants-malades hospital, APHP, Paris Descartes University, Paris, EU, France.
Florence MoulinDepartment of Pediatric Intensive Care Unit, Necker Enfants-Malades Hospital, APHP, Paris Descartes University, Paris, EU, France.
Xavier NassifDepartment of Microbiology, Necker Enfants-malades hospital, APHP, Paris Descartes University, Paris, EU, France.
Louise GalmichePathology Department, Necker Enfants-Malades Hospital, APHP, Paris Descartes University, Paris, EU, France.
Delphine BorgelDepartment of Hematology, Necker Enfants-Malades Hospital, APHP, Paris Descartes University, Paris, EU, France.
Alain CharbitNecker-Enfants-Malades Institute, INSERM U1151; CNRS UMR8253, Paris, France.
Capucine PicardCenter for the Study of Primary Immunodeficiencies, Necker Enfants Malades Hospital, APHP, Paris Descartes University, Paris, EU, France.
Jean-Paul MiraMedical Intensive Care Unit, Cochin Hospital, AP-HP, Paris Descartes University, Paris, EU, France.
Olivier LortholaryDepartment of Infectious Diseases and Tropical Medicine, Necker Enfants-Malades Hospital, Necker-Pasteur Infectious Diseases Center, Université Paris Descartes, IHU Imagine, Paris, EU, France.
Anne JametDepartment of Microbiology, Necker Enfants-malades hospital, APHP, Paris Descartes University, Paris, EU, France.
Julie ToubianaDepartment of Infection, Immunity and Inflammation, Institut Cochin, INSERM U1016, Paris, EU, France. julie.toubiana@aphp.fr.ORCID http://orcid.org/0000-0001-9561-669X
Hôpital Necker-Enfants Malades · FRCentre National de la Recherche Scientifique · FRDélégation Paris 5 · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStaphylococcus aureus has emerged as a leading cause of invasive severe diseases with a high rate of morbidity and mortality worldwide. The wide spectrum of clinical manifestations and outcome observed in staphylococcal illness may be a consequence of both microbial factors and variability of the host immune response. CASE PRESENTATION: A 14-years old child developed limb ischemia with gangrene following S. aureus bloodstream infection. Histopathology revealed medium-sized arterial vasculitis. The causing strain belonged to the emerging clone CC1-MSSA and numerous pathogenesis-related genes were identified. Patient's genotyping revealed functional variants associated with severe infections. A combination of virulence and host factors might explain this unique severe form of staphylococcal disease.

conclusionA combination of virulence and genetic host factors might explain this unique severe form of staphylococcal disease.

Indexed as

AdolescentAmputation, SurgicalAnti-Bacterial AgentsBrainCefotaximeClindamycinHumansLegMagnetic Resonance ImagingMaleMethicillinShock, SepticStaphylococcal InfectionsStaphylococcus aureusVasculitisAnti-Bacterial AgentsCefotaximeClindamycinMethicillinCase reportGenetic susceptibilityPolymorphismS. aureusSepsisVasculitisVirulence

Identifiers

PMID30943907
PMCPMC6446405
OpenAlexW2929844903

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.