Evidence map›Paper›PMID 30943894›Full record

ReviewThe journal of headache and pain2019

Neuroimaging clues of migraine aura.

Nouchine Hadjikhani, Maurice Vincent

Open access · goldAbstract readReview
In one paragraph

Review in The journal of headache and pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Genetic Mechanisms of Migraine: Insights from Monogenic Migraine Mutations.International journal of molecular sciences · 2023
    Review
  4. The NMDA receptor antagonists memantine and ketamine as anti-migraine agents.Naunyn-Schmiedeberg's archives of pharmacology · 2023
    Review
  5. Article
  6. Article
  7. The hypothalamus may mediate migraine and ictal photophobia: evidence from Granger causality analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  8. Article
  9. Article
  10. Aura Mapping: Where Vision and Somatosensation Meet.Vision (Basel, Switzerland) · 2021
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Migraine Aura: Updates in Pathophysiology and Management.Current neurology and neuroscience reports · 2020
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Retinal connections to migraine.Frontiers in neurology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Nouchine HadjikhaniA.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, USA. nouchine@nmr.mgh.harvard.edu.ORCID http://orcid.org/0000-0003-4075-3106
Maurice VincentNeuroscience Research, Eli Lilly and Company, Indianapolis, USA.
Eli Lilly (United States) · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While migraine headaches can be provoked, or predicted by the presence of an aura or premonitory symptoms, the prediction or elicitation of the aura itself is more problematic. Therefore, imaging studies directly examining the aura phenomenon are sparse. There are however interictal imaging studies that can shed light on the pathophysiology of the migraine with aura (MWA) cascade. Here, we review findings pointing to the involvement of cortical spreading depression (CSD) and neuroinflammation in MWA. Whether asymptomatic CSD also happens in some migraine without aura is still under debate. In addition, new evidence points to glial activation in MWA, indicating the involvement of astrocytes in the neuroinflammatory cascade that follows CSD, as well as dural macrophages, supporting the involvement of the trigeminovascular system in migraine pain.

Indexed as

Cortical Spreading DepressionNeuroimagingEpilepsyHumansMigraine DisordersMigraine with AuraNeuroglia(3–10): MigraineAuraBrain imagingCSD

Identifiers

PMID30943894
PMCPMC6734229
OpenAlexW2944347781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.