Evidence map›Paper›PMID 30943765›Full record

ArticleCirculation. Arrhythmia and electrophysiology2019

Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca

Anett H Ottesen, Cathrine R Carlson, Olav Søvik Eken, Mani Sadredini, Peder L Myhre, Xin Shen, Bjørn Dalhus, Derek R Laver, Per Kristian Lunde, Jouni Kurola and 14 more

Open access · hybridAbstract read
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In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  9. Review
  10. A cell permeant phosphopeptide mimetic of Niban inhibits p38 MAPK and restores endothelial function after injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  11. Secretoneurin to the Rescue?: Maybe or Maybe Not.Circulation. Arrhythmia and electrophysiology · 2019
    Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 10 institutions in 7 countries.

Anett H OttesenDivision of Medicine, Akershus University Hospital, Lørenskog, Norway (A.H.O., P.L.M., J.E.H., T.O., H.R.).
Cathrine R CarlsonInstitute for Experimental Medical Research (A.H.O., C.R.C., O.S.E., M. Sadredini, X.S., P.K.L., M.L., I.S., A.G.E., I.G.L., M.K.S., G.C., W.E.L.), Oslo University Hospital, Norway.
Olav Søvik EkenInstitute for Experimental Medical Research (A.H.O., C.R.C., O.S.E., M. Sadredini, X.S., P.K.L., M.L., I.S., A.G.E., I.G.L., M.K.S., G.C., W.E.L.), Oslo University Hospital, Norway.
Mani SadrediniInstitute for Experimental Medical Research (A.H.O., C.R.C., O.S.E., M. Sadredini, X.S., P.K.L., M.L., I.S., A.G.E., I.G.L., M.K.S., G.C., W.E.L.), Oslo University Hospital, Norway.
Peder L MyhreDivision of Medicine, Akershus University Hospital, Lørenskog, Norway (A.H.O., P.L.M., J.E.H., T.O., H.R.).
Xin ShenInstitute for Experimental Medical Research (A.H.O., C.R.C., O.S.E., M. Sadredini, X.S., P.K.L., M.L., I.S., A.G.E., I.G.L., M.K.S., G.C., W.E.L.), Oslo University Hospital, Norway.
Bjørn DalhusDepartment for Microbiology, Clinic for Laboratory Medicine (B.D.), Oslo University Hospital, Norway.
Derek R LaverSchool of Biomedical Sciences and Pharmacy, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia (D.R.L.).
Per Kristian LundeInstitute for Experimental Medical Research (A.H.O., C.R.C., O.S.E., M. Sadredini, X.S., P.K.L., M.L., I.S., A.G.E., I.G.L., M.K.S., G.C., W.E.L.), Oslo University Hospital, Norway.
Jouni KurolaDivision of Intensive Care Medicine, Kuopio University Hospital, Finland (J.K.).
Marianne LundeInstitute for Experimental Medical Research (A.H.O., C.R.C., O.S.E., M. Sadredini, X.S., P.K.L., M.L., I.S., A.G.E., I.G.L., M.K.S., G.C., W.E.L.), Oslo University Hospital, Norway.
Jon Erik HoffDivision of Medicine, Akershus University Hospital, Lørenskog, Norway (A.H.O., P.L.M., J.E.H., T.O., H.R.).
Kristin GodangSection of Specialized Endocrinology, Department of Endocrinology (K.G.), Oslo University Hospital, Norway.
Ivar SjaastadInstitute for Experimental Medical Research (A.H.O., C.R.C., O.S.E., M. Sadredini, X.S., P.K.L., M.L., I.S., A.G.E., I.G.L., M.K.S., G.C., W.E.L.), Oslo University Hospital, Norway.
Ville PettiläDivision of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki & Helsinki University Hospital, Finland (V.P.).
Mats StridsbergDepartment of Medical Sciences, Uppsala University, Sweden (M. Stridsberg).
Stephan E LehnartHeart Research Center Goettingen, University Medicine Center Goettingen, Germany (S.E.L.).
Andrew G EdwardsInstitute for Experimental Medical Research (A.H.O., C.R.C., O.S.E., M. Sadredini, X.S., P.K.L., M.L., I.S., A.G.E., I.G.L., M.K.S., G.C., W.E.L.), Oslo University Hospital, Norway.
Ida G LundeInstitute for Experimental Medical Research (A.H.O., C.R.C., O.S.E., M. Sadredini, X.S., P.K.L., M.L., I.S., A.G.E., I.G.L., M.K.S., G.C., W.E.L.), Oslo University Hospital, Norway.
Torbjørn OmlandDivision of Medicine, Akershus University Hospital, Lørenskog, Norway (A.H.O., P.L.M., J.E.H., T.O., H.R.).
Mathis K StokkeInstitute for Experimental Medical Research (A.H.O., C.R.C., O.S.E., M. Sadredini, X.S., P.K.L., M.L., I.S., A.G.E., I.G.L., M.K.S., G.C., W.E.L.), Oslo University Hospital, Norway.
Geir ChristensenInstitute for Experimental Medical Research (A.H.O., C.R.C., O.S.E., M. Sadredini, X.S., P.K.L., M.L., I.S., A.G.E., I.G.L., M.K.S., G.C., W.E.L.), Oslo University Hospital, Norway.
Helge RøsjøDivision of Medicine, Akershus University Hospital, Lørenskog, Norway (A.H.O., P.L.M., J.E.H., T.O., H.R.).
William E LouchInstitute for Experimental Medical Research (A.H.O., C.R.C., O.S.E., M. Sadredini, X.S., P.K.L., M.L., I.S., A.G.E., I.G.L., M.K.S., G.C., W.E.L.), Oslo University Hospital, Norway.
Norwegian Womens Public Health Association · NOAkershus University Hospital · NOOslo University Hospital · NOHunter Medical Research Institute · AUI.R.C.C.S. Oasi Maria SS · ITMedical Products Agency · SENephrologisches Zentrum Goettingen · DESimula Research Laboratory · NOUniversity of Eastern Finland · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCirculating SN (secretoneurin) concentrations are increased in patients with myocardial dysfunction and predict poor outcome. Because SN inhibits CaMKIIδ (Ca

methodsCirculating levels of SN and other biomarkers were assessed in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT; n=8) and in resuscitated patients after ventricular arrhythmia-induced cardiac arrest (n=155). In vivo effects of SN were investigated in CPVT mice (RyR2 [ryanodine receptor 2]-R2474S) using adeno-associated virus-9-induced overexpression. Interactions between SN and CaMKIIδ were mapped using pull-down experiments, mutagenesis, ELISA, and structural homology modeling. Ex vivo actions were tested in Langendorff hearts and effects on Ca

resultsSN levels were elevated in patients with CPVT and following ventricular arrhythmia-induced cardiac arrest. In contrast to NT-proBNP (N-terminal pro-B-type natriuretic peptide) and hs-TnT (high-sensitivity troponin T), circulating SN levels declined after resuscitation, as the risk of a new arrhythmia waned. Myocardial pro-SN expression was also increased in CPVT mice, and further adeno-associated virus-9-induced overexpression of SN attenuated arrhythmic induction during stress testing with isoproterenol. Mechanistic studies mapped SN binding to the substrate binding site in the catalytic region of CaMKIIδ. Accordingly, SN attenuated isoproterenol induced autophosphorylation of Thr287-CaMKIIδ in Langendorff hearts and inhibited CaMKIIδ-dependent RyR phosphorylation. In line with CaMKIIδ and RyR inhibition, SN treatment decreased Ca

conclusionsSN production is upregulated in conditions with cardiomyocyte Ca

Indexed as

AnimalsBiomarkersCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingHeart ArrestHumansMiceMyocytes, CardiacNatriuretic Peptide, BrainNeuropeptidesPatch-Clamp TechniquesPeptide FragmentsPhosphorylationPolymorphic Catecholaminergic Ventricular TachycardiaRyanodine Receptor Calcium Release ChannelBiomarkersCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Natriuretic Peptide, BrainNeuropeptidesPeptide Fragmentspro-brain natriuretic peptide (1-76)Ryanodine Receptor Calcium Release ChannelSecretogranin IIsecretoneurinTroponin Tcalciumcalmodulinheart failuresecretoneurintachycardia

Identifiers

PMID30943765
OpenAlexW2935250152

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.