ArticlePhysical biology2019
Modeling meiotic chromosome pairing: a tug of war between telomere forces and a pairing-based Brownian ratchet leads to increased pairing fidelity.
Article in Physical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- ZCWPW1 organizes telomeric architecture to drive meiotic chromosome movements.bioRxiv : the preprint server for biology · 2026Article
- Using wheat-rye 1BL.1RS translocations to disclose the effects of subtelomeric tandem repeats on meiotic behavior of homologues.BMC plant biology · 2026Article
- Modeling homologous chromosome recognition via nonspecific interactions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Agent-based modeling of nuclear chromosome ensembles identifies determinants of homolog pairing during meiosis.PLoS computational biology · 2024Article
- Agent-based modeling of nuclear chromosome ensemble identifies determinants of homolog pairing during meiosis.bioRxiv : the preprint server for biology · 2024Article
- Beyond tradition: exploring the non-canonical functions of telomeres in meiosis.Frontiers in cell and developmental biology · 2023Article
- Modeling cell biological features of meiotic chromosome pairing to study interlock resolution.PLoS computational biology · 2022Article
- Review
- Diffusion and distal linkages govern interchromosomal dynamics during meiotic prophase.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Telomeres and Subtelomeres Dynamics in the Context of Early Chromosome Interactions During Meiosis and Their Implications in Plant Breeding.Frontiers in plant science · 2021Review
- Sequence analysis of wheat subtelomeres reveals a high polymorphism among homoeologous chromosomes.The plant genome · 2020Article
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2 authors.
Funding
Abstract
Meiotic homolog pairing involves associations between homologous DNA regions scattered along the length of a chromosome. When homologs associate, they tend to do so by a processive zippering process, which apparently results from avidity effects. Using a computational model, we show that this avidity-driven processive zippering reduces the selectivity of pairing. When active random forces are applied to telomeres, this drop in selectivity is eliminated in a force-dependent manner. Further simulations suggest that active telomere forces are engaged in a tug-of-war against zippering, which can be interpreted as a Brownian ratchet with a stall force that depends on the dissociation constant of pairing. When perfectly homologous regions of high affinity compete with homeologous regions of lower affinity, the affinity difference can be amplified through this tug of war effect provided the telomere force acts in a range that is strong enough to oppose zippering of homeologs while still permitting zippering of correct homologs. The degree of unzippering depends on the radius of the nucleus, such that complete unzippering of homeologous regions can only take place if the nucleus is large enough to pull the two chromosomes completely apart. A picture of meiotic pairing thus emerges that is fundamentally mechanical in nature, possibly explaining the purpose of active telomere forces, increased nuclear diameter, and the presence of 'Maverick' chromosomes in meiosis.
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