ArticleCell reports2019
HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 205 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed, 1 pooled it
12.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
205 citing papers in PubMed, 1 synthesis or guideline pooled it, 294 citations in OpenAlex.
- Interaction of HIF-1a with various cell death pathways in tumor immune microenvironment (TIME).Apoptosis : an international journal on programmed cell death · 2026Pooled it
- HDCA suppresses exosomal lncRNA MSTRG171708 release to inhibit Treg-mediated immunometabolism in hepatocellular carcinoma.Molecular biomedicine · 2026Article
- Fatty Acid Metabolism Rewires Glioblastoma Progression and Treg-Mediated Immune Resistance.Cancers · 2026Review
- FAM234A acts as a switch between Th17 and Treg cell fate decisions that control inflammatory bowel disease.Cellular & molecular immunology · 2026Article
- The Glucose Transporter GLUT3 Controls Regulatory T Cell Function.European journal of immunology · 2026Article
- The perinecrotic niche of glioblastoma drives tumor-associated macrophage polarization and immunosuppression via podoplanin-mediated CLEC5A activation.The Journal of clinical investigation · 2026Article
- CD36 as a Context-Dependent Regulator of Metabolic Switching in Acute and Chronic Hypoxia.Biomolecules · 2026Review
- Emerging roles of ferroptosis in modulating the immune landscape of glial tumours.Nature cell biology · 2026Review
- T-Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan-Cancer Characteristics, and Therapeutic Interventions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging.Cancer science · 2026Review
- Lactate Uptake by MCT4 Facilitates Stability and Suppressive Function of Tumor-Infiltrating Regulatory T Cells by Promoting Foxp3 Lactylation.International journal of molecular sciences · 2026Article
- Next-Generation regulatory T cell therapies: Translational considerations for inflammatory bowel disease.Human immunology · 2026Review
- Metabolic adaptations of immunosuppressive cells in cancer: mechanisms and therapeutic targets.Experimental & molecular medicine · 2026Review
- Glucose metabolic reprogramming as a driver of immunosuppression in the tumour microenvironment.Clinical and translational medicine · 2026Review
- The pyruvate branch point controls lymphoid cancer cell dissemination.bioRxiv : the preprint server for biology · 2026Article
- Targeting tumor-infiltrating regulatory T cells based on immunometabolism.Cancer biology & medicine · 2026Review
- SUMOylation is destined for regulatory T cell-related immune dysregulation.Cell death discovery · 2026Review
- Reductive stress in cancer immunology and targeted therapy.Acta biochimica et biophysica Sinica · 2026Review
- Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity.Science advances · 2026Article
145 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 2 institutions in 1 country.
Jason MiskaDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Catalina Lee-ChangDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Aida RashidiDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Megan E MuroskiDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Alan L ChangDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Aurora Lopez-RosasDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Peng ZhangDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Wojciech K PanekDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Alex CorderoDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Yu HanDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Atique U AhmedDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA.
Navdeep S ChandelDepartment of Medicine, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2330, Chicago, IL 60611, USA.
Maciej S LesniakDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA. Electronic address: maciej.lesniak@northwestern.edu.
Northwestern University · USNeurological Surgery · US
Funding
STINGing GBM: A First-in- Man Clinical Trial in Surgical Resectable Recurrent GBMP50CA221747 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Catalina Lee Chang · 2018 to 2026
$21.4MMitochondrial metabolism and ROS regulate cancerR35CA197532 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2016 to 2022
$6.3MTherapeutic Targeting of Malignant Glioma Stem CellsR35CA197725 · NCI · UNIVERSITY OF CHICAGO · PI LESNIAK, MACIEJ S · 2015 to 2021
$6.2MMetabolic Control of Immune Suppression in GliomasR01NS093903 · NINDS · UNIVERSITY OF CHICAGO · PI LESNIAK, MACIEJ S · 2015 to 2019
$2.3MIntranasal Stem-Cell Based Therapy for GlioblastomaR01NS087990 · NINDS · UNIVERSITY OF CHICAGO · PI BALYASNIKOVA, IRINA V · 2014 to 2018
$2.1MArginine Metabolism Regulates Myeloid Immune Suppression in GlioblastomaR01NS115955 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LESNIAK, MACIEJ S, MISKA, JASON · 2020 to 2024
$1.9MRegulatory T Cells in Malignant GliomaR01CA138587 · NCI · UNIVERSITY OF CHICAGO · PI LESNIAK, MACIEJ S · 2009 to 2013
$1.6MThe Role of Glioma Metabolism in Promoting Tumor ImmunosuppressionF32NS098737 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MISKA, JASON · 2017 to 2018
$122kNCI NIH HHS P50 CA221747NCI NIH HHS R01 CA138587NCI NIH HHS R35 CA197532NCI NIH HHS R35 CA197725NINDS NIH HHS F32 NS098737NINDS NIH HHS R01 NS087990NINDS NIH HHS R01 NS093903NINDS NIH HHS R01 NS115955
Abstract
The mechanisms by which regulatory T cells (Tregs) migrate to and function within the hypoxic tumor microenvironment are unclear. Our studies indicate that specific ablation of hypoxia-inducible factor 1α (HIF-1α) in Tregs results in enhanced CD8
Indexed as
Brain NeoplasmsGlioblastomaTumor EscapeAgedAged, 80 and overAnimalsCell HypoxiaCell MovementCells, CulturedEnergy MetabolismFemaleGenes, SwitchGlycolysisHumansHypoxia-Inducible Factor 1, alpha SubunitImmunosuppression TherapyHIF1A protein, humanHypoxia-Inducible Factor 1, alpha Subunitfatty acid oxidationglioblastomaglycolysisimmunosuppressionmigrationoxidative phosphorylationregulatory T cell
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.