Evidence map›Paper›PMID 30943377›Full record

ArticleAmerican journal of respiratory cell and molecular biology2019

Bronchial Epithelial Calcium Metabolism Impairment in Smokers and Chronic Obstructive Pulmonary Disease. Decreased ORAI3 Signaling.

Aurelie Petit, Lucie Knabe, Kamel Khelloufi, Myriam Jory, Delphine Gras, Yann Cabon, Malcolm Begg, Sylvain Richard, Gladys Massiera, Pascal Chanez and 2 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Vaping-Dependent Pulmonary Inflammation Is CaInternational journal of molecular sciences · 2024
    Article
  7. Airway ciliated cells in adult lung homeostasis and COPD.European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  8. Review
  9. Reduction of TRPC1/TRPC3 mediated CaCellular signalling · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Nanoparticle Delivery Systems with Cell-Specific Targeting for Pulmonary Diseases.American journal of respiratory cell and molecular biology · 2021
    Review
  17. Review
  18. Update in Chronic Obstructive Pulmonary Disease 2019.American journal of respiratory and critical care medicine · 2020
    Review
  19. Review
  20. Mitochondrial Contact Sites in Inflammation-Induced Cardiovascular Disease.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Aurelie PetitDepartment of Respiratory Diseases and Addictology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, Montpellier, France.
Lucie KnabeDepartment of Respiratory Diseases and Addictology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, Montpellier, France.
Kamel KhelloufiCNRS, Centre Interdisciplinaire de Nanoscience de Marseille UMR 7325, and.
Myriam JoryUMR 5221 CNRS, Laboratoire Charles Coulomb (L2C), Montpellier, France.
Delphine GrasAssistance Publique Hôpitaux de Marseille (APHM), Centre de recherche en CardioVasculaire et Nutrition, INSERM U1263 Institut National de la Recherche Agronomique (INRA) 1260, Clinique des Bronches Allergies et Sommeil, Aix Marseille University, Marseille, France.
Yann CabonDepartment of Medical Information, Montpellier University Hospital, Montpellier, France; and.
Malcolm BeggRefractory Respiratory Inflammation Data Processing Unit, Respiratory TAU, GlaxoSmithKline, Stevenage, United Kingdom.
Sylvain RichardInstitut National de la Santé et de la Recherche Médicale (INSERM) U1046, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 9214, University of Montpellier, Montpellier, France.
Gladys MassieraUMR 5221 CNRS, Laboratoire Charles Coulomb (L2C), Montpellier, France.
Pascal ChanezAssistance Publique Hôpitaux de Marseille (APHM), Centre de recherche en CardioVasculaire et Nutrition, INSERM U1263 Institut National de la Recherche Agronomique (INRA) 1260, Clinique des Bronches Allergies et Sommeil, Aix Marseille University, Marseille, France.
Isabelle VachierDepartment of Respiratory Diseases and Addictology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, Montpellier, France.
Arnaud BourdinDepartment of Respiratory Diseases and Addictology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, Montpellier, France.
Centre National de la Recherche Scientifique · FRHôpital Arnaud de Villeneuve · FRInserm · FRCentre Interdisciplinaire de Nanoscience de Marseille · FRGlaxoSmithKline (United Kingdom) · GBUniversité de Montpellier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The airway epithelium represents a fragile environmental interface potentially disturbed by cigarette smoke (CS), the major risk factor for developing chronic obstructive pulmonary disease (COPD). CS leads to bronchial epithelial damage on ciliated, goblet, and club cells, which could involve calcium (Ca

Indexed as

AdultAgedBenzamidesBronchiCalciumCalcium ChannelsCalcium SignalingCells, CulturedCiliaCytokinesEndoplasmic ReticulumEpithelial CellsFemaleGene Expression RegulationHumansInterleukin-82,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamideBenzamidesCalciumCalcium ChannelsCytokinesInterleukin-8MUC5AC protein, humanMucin 5ACOrai3 protein, humanPyrazolesSmokebronchial epithelial cellscalcium signalingcigarette smokeORAI3

Identifiers

PMID30943377
OpenAlexW2928971587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.