ArticleJournal of neurophysiology2019
Hair cell and neural contributions to the cochlear summating potential.
Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 68 citations in OpenAlex.
- TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non-Syndromic Hearing Loss.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Can Mismatch Negativity Be Used as an Indicator to Predict Central Auditory Deficits in Individuals with Normal Hearing?Audiology research · 2025Article
- Cochlear Synaptopathy Evaluation With Electrocochleography in Patients With Hearing Difficulty in Noise Despite Normal Hearing Levels.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025Article
- Validating an Evoked Potential Platform for Electrocochleography During Cochlear Implantation.The Laryngoscope · 2025Article
- ZH-ECochG Bode Plot: A Novel Approach to Visualize Electrocochleographic Data in Cochlear Implant Users.Journal of clinical medicine · 2024Article
- Identifying Slim Modiolar Electrode Tip Fold-Over With Intracochlear Electrocochleography.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024Article
- Evidence of cochlear neural degeneration in normal-hearing subjects with tinnitus.Scientific reports · 2023Article
- Development of an audiological assessment and diagnostic model for high occupational noise exposure.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- The summating potential polarity encodes the ear health condition.Cellular and molecular life sciences : CMLS · 2023Article
- Minimum Detectable Differences in Electrocochleography Measurements: Bayesian-Based Predictions.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Computational modeling of the human compound action potential.The Journal of the Acoustical Society of America · 2023Article
- Isolating auditory-nerve contributions to electrocochleography by high-pass filtering: A better biomarker for cochlear nerve degeneration?JASA express letters · 2023Article
- Assessment of cochlear synaptopathy by electrocochleography to low frequencies in a preclinical model and human subjects.Frontiers in neurology · 2023Article
- Relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity.JASA express letters · 2022Article
- Objective Detection of Tinnitus Based on Electrophysiology.Brain sciences · 2022Review
- Neural Contributions to the Cochlear Summating Potential: Spiking and Dendritic Components.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Optimizing non-invasive functional markers for cochlear deafferentation based on electrocochleography and auditory brainstem responses.The Journal of the Acoustical Society of America · 2022Article
- Relations between speech-reception, psychophysical temporal processing, and subcortical electrophysiological measures of auditory function in humans.Hearing research · 2022Article
- The hunt for hidden hearing loss in humans: From preclinical studies to effective interventions.Frontiers in neuroscience · 2022Review
- Lack of neural contributions to the summating potential in humans with Meniere's disease.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
The cochlear summating potential (SP) to a tone is a baseline shift that persists for the duration of the burst. It is often considered the most enigmatic of cochlear potentials because its magnitude and polarity vary across frequency and level and its origins are uncertain. In this study, we used pharmacology to isolate sources of the SP originating from the gerbil cochlea. Animals either had the full complement of outer and inner hair cells (OHCs and IHCs) and an intact auditory nerve or had systemic treatment with furosemide and kanamycin (FK) to remove the outer hair cells. Responses to tone bursts were recorded from the round window before and after the neurotoxin kainic acid (KA) was applied. IHC responses were then isolated from the post-KA responses in FK animals, neural responses were isolated from the subtraction of post-KA from pre-KA responses in NH animals, and OHC responses were isolated by subtraction of post-KA responses in FK animals from post-KA responses in normal hearing (NH) animals. All three sources contributed to the SP; OHCs with a negative polarity and IHCs and the auditory nerve with positive polarity. Thus the recorded SP in NH animals is a sum of contributions from different sources, contributing to the variety of magnitudes and polarities seen across frequency and intensity. When this information was applied to observations of the SP recorded from the round window in human cochlear implant subjects, a strong neural contribution to the SP was confirmed in humans as well as gerbils.
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Registered trials
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