Evidence map›Paper›PMID 30943068›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo.

Jing Li, Sylvia Cechova, Lina Wang, Brant E Isakson, Thu H Le, Weibin Shi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jing LiDepartment of Radiology and Medical Imaging, University of Virginia , Charlottesville, Virginia.
Sylvia CechovaDepartment of Medicine, University of Virginia , Charlottesville, Virginia.
Lina WangDepartment of Medicine, University of Virginia , Charlottesville, Virginia.
Brant E IsaksonRobert M. Berne Cardiovascular Research Center, University of Virginia , Charlottesville, Virginia.
Thu H LeDepartment of Medicine, University of Virginia , Charlottesville, Virginia.
Weibin ShiDepartment of Radiology and Medical Imaging, University of Virginia , Charlottesville, Virginia.
University of Virginia · USAffiliated Hospital of Qingdao University · CN

Funding

Mechanisms of Heterocellular Signaling at the Myoenothelial JunctionR01HL088554 · NHLBI · UNIVERSITY OF VIRGINIA · PI ISAKSON, BRANT E, WEISS, MITCHELL J · 2008 to 2017
$3.8M
Renal Mechanisms of Blood Pressure Regulation and Salt Sensitivity by CollectrinR01DK113632 · NIDDK · UNIVERSITY OF VIRGINIA · PI LE, THU H. · 2017 to 2021
$1.8M
GSTM1, APOL1, and their joint contribution to severity of hypertension and chronic kidney diseaseR01DK094907 · NIDDK · UNIVERSITY OF VIRGINIA · PI LE, THU H., MYCHALECKYJ, JOSYF · 2012 to 2021
$1.7M
Genetic connections between type 2 diabetes and atherosclerosisR01DK116768 · NIDDK · UNIVERSITY OF VIRGINIA · PI SHI, WEIBIN · 2019 to 2022
$1.6M
Genetic link between type 2 diabetes and atherosclerosisR01DK097120 · NIDDK · UNIVERSITY OF VIRGINIA · PI SHI, WEIBIN · 2013 to 2016
$1.4M
NHLBI NIH HHS R01 HL088554NIDDK NIH HHS R01 DK094907NIDDK NIH HHS R01 DK097120NIDDK NIH HHS R01 DK113632NIDDK NIH HHS R01 DK116768
6 · The paper itself

Abstract

Hypertension affects over 1 billion people worldwide and increases the risk for heart failure, stroke, and chronic kidney disease. Despite high prevalence and devastating impact, its etiology still remains poorly understood for most hypertensive cases.

Indexed as

Angiotensin IIBlood PressureAnimalsCalcium-Binding ProteinsCells, CulturedDisease Models, AnimalEndothelial CellsHumansHypertensionKidneyMaleMice, Inbred C57BLMice, KnockoutNitric OxideNitric Oxide Synthase Type IIIRNA, Small InterferingAngiotensin IICalcium-Binding ProteinsNitric OxideNitric Oxide Synthase Type IIINos3 protein, mouseRCN2 protein, humanRcn2 protein, mouseRNA, Small Interferingblood pressurehypertensionmicenitric oxidereticulocalbin 2

Identifiers

PMID30943068
PMCPMC6620588
OpenAlexW2929159272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.