Evidence map›Paper›PMID 30943058›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2019

Stimulation of spinal δ-opioid receptors attenuates the exercise pressor reflex in decerebrate rats.

Joyce S Kim, Marc P Kaufman

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. No effect of endoperoxide 4 or thromboxane AExperimental physiology · 2020
    Article
  4. Article
  5. Thromboxane AAmerican journal of physiology. Heart and circulatory physiology · 2020
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joyce S KimPennsylvania State Heart and Vascular Institute and Department of Internal Medicine, Pennsylvania State College of Medicine , Hershey, Pennsylvania.ORCID 0000-0002-8505-7887
Marc P KaufmanPennsylvania State Heart and Vascular Institute and Department of Internal Medicine, Pennsylvania State College of Medicine , Hershey, Pennsylvania.
Penn State Milton S. Hershey Medical Center · US

Funding

Project 3: Role Played by ASIC, P2X and EP4 Receptors in the Exercise Pressor Reflex in Health and Simulated PADP01HL134609 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KAUFMAN, MARC PETER · 2017 to 2021
$9.4M
Excitability of Afferents Evoking the Exercise Pressor ReflexR01AR059397 · NIAMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ELMSLIE, KEITH S, KAUFMAN, MARC PETER · 2010 to 2019
$5.4M
NHLBI NIH HHS P01 HL134609NIAMS NIH HHS R01 AR059397
6 · The paper itself

Abstract

A reflex arising from contracting hindlimb muscle is responsible in part for the increases in arterial pressure and heart rate evoked by exercise. The afferent arm of this reflex comprises group III and IV afferents. δ-Opioid receptors are expressed predominately on the spinal endings of group III afferents, whereas μ-opioid receptors are expressed predominately on the spinal endings of group IV afferents. Using stimuli that activated group III afferents, namely static contraction, calcaneal tendon stretch, and lactic acid injection into the superficial epigastric artery, we tested the hypothesis that, in rats with either patent or ligated femoral arteries, activation of pre- and postsynaptic δ-opioid receptors in the dorsal horn attenuated pressor reflex responses to these stimuli. In rats with patent arteries or ligated femoral arteries, [d-Pen

Indexed as

AnimalsDecerebrate StateEnkephalin, D-Penicillamine (2,5)-Femoral ArteryHeart RateMaleMuscle ContractionMuscle, SkeletalPhysical Conditioning, AnimalPhysical ExertionRats, Sprague-DawleyReceptors, Opioid, deltaReceptors, Opioid, muReflexEnkephalin, D-Penicillamine (2,5)-Receptors, Opioid, deltaReceptors, Opioid, muautonomic nervous systemcapsaicinlactic acidstatic contractionsympathetic nervous systemtendon stretch

Identifiers

PMID30943058
PMCPMC6620654
OpenAlexW2929455105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.