Evidence map›Paper›PMID 30942955›Full record

ArticleMacromolecular bioscience2019

Implantable Nanotube Sensor Platform for Rapid Analyte Detection.

Eric Michael Hofferber, Joseph Anthony Stapleton, Janelle Adams, Mitchell Kuss, Bin Duan, Nicole Marie Iverson

Abstract read
In one paragraph

Article in Macromolecular bioscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eric Michael HofferberDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, 233 L. W. Chase Hall, Lincoln, NE, 68583-0726, USA.ORCID 0000-0002-5993-9018
Joseph Anthony StapletonDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, 233 L. W. Chase Hall, Lincoln, NE, 68583-0726, USA.
Janelle AdamsDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, 233 L. W. Chase Hall, Lincoln, NE, 68583-0726, USA.
Mitchell KussRegenerative Medicine Program, University of Nebraska Medical Center, DRC II 6035, UNMC, Omaha, NE, 68198-5965, USA.
Bin DuanRegenerative Medicine Program, University of Nebraska Medical Center, DRC II 6035, UNMC, Omaha, NE, 68198-5965, USA.
Nicole Marie IversonDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, 233 L. W. Chase Hall, Lincoln, NE, 68583-0726, USA.ORCID 0000-0002-5166-1410

Funding

Targeted mass spectrometry approaches to understand CART processing and recepter interactionsP20GM113126 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GUO, JIANTAO · 2016 to 2025
$20.8M
NIGMS NIH HHS P20 GM113126
6 · The paper itself

Abstract

The use of nanoparticles within living systems is a growing field, but the long-term effects of introducing nanoparticles to a biological system are unknown. If nanoparticles remain localized after in vivo implantation unanticipated side effects due to unknown biodistribution can be avoided. Unfortunately, stabilization and retention of nanoparticles frequently alters their function.[1] In this work multiple hydrogel platforms are developed to look at long-term localization of nanoparticle sensors with the goal of developing a sensor platform that will stabilize and localize the nanoparticles without altering their function. Two different hydrogel platforms are presented, one with a liquid core of sensors and another with sensors decorating the hydrogel's exterior, that are capable of localizing the nanoparticles without inhibiting their function. With the use of these new hydrogel platforms nanoparticle sensors can be easily implanted in vivo and utilized without concerns of nanoparticle impact on the animal.

Indexed as

Biosensing TechniquesAlginatesHumansHyaluronic AcidHydrogelsMaterials TestingNanoparticlesNanotubes, CarbonAlginatesHyaluronic AcidHydrogelsNanotubes, Carbonbiocompatibilitybiomaterialshydrogelsmolecular recognitionnanotechnology

Identifiers

PMID30942955
PMCPMC6827871

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.