ArticleMolecular medicine reports2019
Prenatal nicotine exposure induces depression‑like behavior in adolescent female rats via modulating neurosteroid in the hippocampus.
Article in Molecular medicine reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Prenatal tobacco use and the risk of mood disorders in offspring: a systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2020Pooled it
- Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model.Journal of applied toxicology : JAT · 2026Article
- Anxiety, Depression, and Emotional Dysregulation Following Prenatal Substance Exposure.Advances in experimental medicine and biology · 2026Review
- Embryonic Nicotine Exposure Disrupts Adult Social Behavior and Craniofacial Development in Zebrafish.Toxics · 2022Article
- Article
- Article
- Sex Differences in the Behavioural Outcomes of Prenatal Nicotine and Tobacco Exposure.Frontiers in neuroscience · 2022Review
- Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature.Brain sciences · 2021Review
- Prenatal risk factors for internalizing and externalizing problems in childhood.World journal of pediatrics : WJP · 2020Review
- Neuroinflammatory and Behavioral Outcomes Measured in Adult Offspring of Mice Exposed Prenatally to E-Cigarette Aerosols.Environmental health perspectives · 2020Article
- A Positive Role of Negative Mood on Creativity: The Opportunity in the Crisis of the COVID-19 Epidemic.Frontiers in psychology · 2020Article
- Selective Expression of Nicotinic Receptor Sub-unit mRNA in Early Human Fetal Forebrain.Frontiers in molecular neuroscience · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal nicotine exposure (PNE) is closely related to depression in offspring. However, the underlying mechanism is still unclear. We hypothesized that neurosteroid in the hippocampus may mediate PNE‑induced depression‑like behaviors. Nicotine was subcutaneously administered (1.0 mg/kg) to pregnant rats twice daily from gestational day (GD) 9 to 20. In adolescent offspring, PNE significantly increased immobility time and decreased the sucrose preference in female rats. The numbers of hippocampal neurons declined in the CA3 and DG regions. Steroidogenic acute regulatory protein (StAR) expression was suppressed in female rats. In fetal offspring, the neuronal numbers of CA3 regions in PNE female fetal hippocampal were significantly decreased, accompanied by the enhanced content of corticosterone and StAR expression. These data indicated that PNE induced depression‑like behavior in adolescent female rats via the regulation of neurosteroid levels in the hippocampus.
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Registered trials
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