ArticleVirchows Archiv. A, Pathological anatomy and histopathology1986
Intermediate-filament expression in thyroid gland carcinomas.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 36 citations in OpenAlex.
- Pattern of expression of intermediate cytokeratin filaments in the thyroid gland: an immunohistochemical study of simple and stratified epithelial-type cytokeratins.Virchows Archiv : an international journal of pathology · 1997Article
- Peripheral Nerve Sheath Tumors of the Thyroid Gland: A Series of Four Cases and a Review of the Literature.Endocrine pathology · 1996Article
- The utility of some modern techniques in understanding thyroid pathology.Endocrine pathology · 1990Review
- Coexpression of cytokeratin, neurofilament and vimentin in carcinoid tumors.Virchows Archiv. A, Pathological anatomy and histopathology · 1989Article
- Coexpression of cytokeratins and vimentin in common epithelial tumours of the ovary: an immunocytochemical study of eighty-three cases.Virchows Archiv. A, Pathological anatomy and histopathology · 1988Article
- Choroid plexus tumors. An immunocytochemical study with particular reference to the coexpression of intermediate filament proteins.The American journal of pathology · 1987Article
- Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry.The American journal of pathology · 1987Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paraffin-embedded specimens of 200 primary thyroid carcinomas were examined immunohistologically for the expression of intermediate-filament (IF) protein of the cytokeratin, vimentin and neurofilament type. In 36 cases, snap-frozen tissue was available, and double label immunofluorescence microscopy was performed in 23 of them. Cytokeratin reactivity was found in all cells of all follicular, papillary and medullary carcinoma cases examined. Using a monoclonal vimentin antibody, positive staining was found in many, though not all cells of the papillary tumours and in approximately 50% of the follicular and the medullary carcinomas. Among anaplastic carcinomas, some tumours were positive for cytokeratins, with or without coexpression of vimentin. Neurofilaments could only be demonstrated in approximately 13% of medullary tumours which in general also exhibited vimentin positivity. The differences of IF expression in follicle and C-cell thyroid carcinomas and the broad variation of cytokeratin and vimentin immunoreactivity among anaplastic tumours of this organ is discussed in relation to the possible intrinsic heterogeneity of these tumours and the diagnostic value of these markers.
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