Evidence map›Paper›PMID 30942116›Full record

ArticleRenal failure2019

High neutrophil/lymphocyte ratio is associated with poor renal outcomes in Japanese patients with chronic kidney disease.

Ryota Yoshitomi, Masaru Nakayama, Teppei Sakoh, Akiko Fukui, Eisuke Katafuchi, Makiko Seki, Susumu Tsuda, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

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Article in Renal failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ryota Yoshitomia Department of Medicine and Clinical Science, Graduate School of Medical Sciences , Kyushu University , Higashi-ku , Japan.
Masaru Nakayamab Division of Nephrology and Clinical Research Institute, Department of Internal Medicine , National Hospital Organization Kyushu Medical Center , Chuo-ku , Japan.
Teppei Sakohb Division of Nephrology and Clinical Research Institute, Department of Internal Medicine , National Hospital Organization Kyushu Medical Center , Chuo-ku , Japan.
Akiko Fukuib Division of Nephrology and Clinical Research Institute, Department of Internal Medicine , National Hospital Organization Kyushu Medical Center , Chuo-ku , Japan.
Eisuke Katafuchib Division of Nephrology and Clinical Research Institute, Department of Internal Medicine , National Hospital Organization Kyushu Medical Center , Chuo-ku , Japan.
Makiko Sekib Division of Nephrology and Clinical Research Institute, Department of Internal Medicine , National Hospital Organization Kyushu Medical Center , Chuo-ku , Japan.
Susumu Tsudab Division of Nephrology and Clinical Research Institute, Department of Internal Medicine , National Hospital Organization Kyushu Medical Center , Chuo-ku , Japan.
Toshiaki Nakanoa Department of Medicine and Clinical Science, Graduate School of Medical Sciences , Kyushu University , Higashi-ku , Japan.
Kazuhiko Tsuruyac Division of Nephrology , Nara Medical University , Kashihara , Japan.
Takanari Kitazonoa Department of Medicine and Clinical Science, Graduate School of Medical Sciences , Kyushu University , Higashi-ku , Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies have shown that the neutrophil/lymphocyte ratio (NLR) is a marker that reflects the state of systemic inflammation. A high NLR was reported to be associated with cardiovascular events and mortality. However, little is known about the association between NLR and kidney disease progression in patients with chronic kidney disease (CKD). Therefore, the aim of the present study was to determine whether NLR is associated with renal outcomes in CKD patients.

methodsThis prospective observational study included 350 consecutive patients with stage 1-4 CKD treated between June 2009 and November 2016. Data were collected until June 2017. The endpoint was the composite of end-stage renal disease requiring dialysis or death. Subjects were divided into two groups according to high and low NLR levels. A Cox proportional hazards model was used to determine the risk factors for composite outcomes.

resultsThe composite endpoint was observed in 83 patients during the median follow-up period of 31.8 months: 29 in the low NLR group and 54 in the high NLR group. Multivariable analysis showed that the high NLR group had a significant increase in the hazard ratio (HR) for composite outcomes (HR 1.67, 95% confidence interval 1.02-2.77) compared with the low NLR group.

conclusionThe present study demonstrated that a high NLR was associated with poor renal outcomes, suggesting that NLR may be a useful marker for prognostic prediction in patients with CKD.

Indexed as

LymphocytesNeutrophilsAdultAgedAged, 80 and overBiomarkersDisease ProgressionFemaleGlomerular Filtration RateHumansJapanKaplan-Meier EstimateKidneyLymphocyte CountMaleMiddle AgedBiomarkerschronic inflammationchronic kidney diseaseNeutrophil/lymphocyte ratiorenal outcome

Identifiers

PMID30942116
PMCPMC6450582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.