Evidence map›Paper›PMID 30941853›Full record

ArticleTraffic (Copenhagen, Denmark)2019

Protein kinase A-mediated phosphorylation of naked cuticle homolog 2 stimulates cell-surface delivery of transforming growth factor-α for epidermal growth factor receptor transactivation.

Zheng Cao, Bhuminder Singh, Cunxi Li, Nicholas O Markham, Léolène J Carrington, Jeffrey L Franklin, Ramona Graves-Deal, Eileen J Kennedy, James R Goldenring, Robert J Coffey

Open access · hybridAbstract read
In one paragraph

Article in Traffic (Copenhagen, Denmark), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Zheng CaoDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Bhuminder SinghDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0003-1357-2158
Cunxi LiJiaen Genetics Laboratory, Beijing Jiaen Hospital, Beijing, China.
Nicholas O MarkhamDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-1348-1267
Léolène J CarringtonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-7352-3270
Jeffrey L FranklinDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-7111-4449
Ramona Graves-DealDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Eileen J KennedyDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia.ORCID 0000-0001-5610-1677
James R GoldenringEpithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-7833-2940
Robert J CoffeyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-2180-3844
Vanderbilt University · USBeijing Jiaotong University · CNUniversity of Georgia · USVanderbilt University Medical Center · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Understanding and Controlling p120 Dysfunction in CRCP50CA095103 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2002 to 2017
$33.6M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
SMALL GTP BINDING PROTEINS IN GASTROINTESTINAL MUCOSAR01DK048370 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOLDENRING, JAMES RICHARD · 1994 to 2025
$10.1M
Integrated approach to study early and late events in colonic neoplasia: mouse to manR35CA197570 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2017 to 2026
$9.4M
Molecular characteristics of the apical recycling systemR01DK070856 · NIDDK · VANDERBILT UNIVERSITY · PI GOLDENRING, JAMES RICHARD · 2006 to 2014
$3.1M
Targeted Inhibition of EGFR DimerizationR03CA188439 · NCI · UNIVERSITY OF GEORGIA · PI KENNEDY, EILEEN J · 2015 to 2016
$150k
NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA095103NCI NIH HHS R03 CA188439NCI NIH HHS R35 CA197570NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK048370NIDDK NIH HHS R01 DK070856
6 · The paper itself

Abstract

The classic mode of G protein-coupled receptor (GPCR)-mediated transactivation of the receptor tyrosine kinase epidermal growth factor receptor (EGFR) transactivation occurs via matrix metalloprotease (MMP)-mediated cleavage of plasma membrane-anchored EGFR ligands. Herein, we show that the Gαs-activating GPCR ligands vasoactive intestinal peptide (VIP) and prostaglandin E

Indexed as

Adaptor Proteins, Signal TransducingA Kinase Anchor ProteinsAnimalsCaco-2 CellsCalcium-Binding ProteinsCell Cycle ProteinsCell MembraneCyclic AMP-Dependent Protein KinasesDinoprostoneDogsErbB ReceptorsHEK293 CellsHumansMadin Darby Canine Kidney CellsProtein TransportSignal TransductionAdaptor Proteins, Signal TransducingAKAP12 protein, humanA Kinase Anchor ProteinsCalcium-Binding ProteinsCell Cycle ProteinsCyclic AMP-Dependent Protein KinasesDinoprostoneErbB ReceptorsNKD2 protein, humanTransforming Growth Factor alphaVasoactive Intestinal PeptideA-kinase anchoring protein 12 (AKAP12)EGFR transactivationepidermal growth factor receptor (EGFR)G protein-coupled receptor (GPCR)naked cuticle homolog 2 (NKD2)protein kinase A (PKA)transforming growth factor-α (TGFα)

Identifiers

PMID30941853
PMCPMC6618044
OpenAlexW2931587144

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.