ArticleHuman brain mapping2019
Distinct and opposite profiles of connectivity during self-reference task and rest in youth at clinical high risk for psychosis.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Real-time neurofeedback, its neurotransmitter underpinnings, and therapeutic effects: study protocol for a randomized controlled trial in individuals at clinical high risk.BMC psychiatry · 2025Article
- Self-concept and Narrative Identity in Youth at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2024Article
- Causal Roles of Ventral and Dorsal Neural Systems for Automatic and Control Self-Reference Processing: A Function Lesion Mapping Study.Journal of clinical medicine · 2024Article
- Temporal Properties of Self-Prioritization.Entropy (Basel, Switzerland) · 2024Article
- A functional neuroimaging study of self-other processing alterations in atypical developmental trajectories of psychotic-like experiences.Scientific reports · 2022Article
- Interactions between the cortical midline structures and sensorimotor network track maladaptive self-beliefs in clinical high risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Depression and Psychosis Risk Shared Vulnerability for Motor Signs Across Development, Symptom Dimensions, and Familial Risk.Schizophrenia bulletin · 2022Article
- Psychosis risk individuals show poor fitness and discrepancies with objective and subjective measures.Scientific reports · 2021Observational
- Overcoming Rest-Task Divide-Abnormal Temporospatial Dynamics and Its Cognition in Schizophrenia.Schizophrenia bulletin · 2021Article
- The Self and Its Prolonged Intrinsic Neural Timescale in Schizophrenia.Schizophrenia bulletin · 2021Article
- Structural and functional imaging markers for susceptibility to psychosis.Molecular psychiatry · 2020Review
- Resting-state functional connectivity of neural circuits associated with primary and secondary rewards in patients with bipolar disorder.Social cognitive and affective neuroscience · 2020Article
- Sleep/Wake Regularity Associated with Default Mode Network Structure among Healthy Adolescents and Young Adults.Scientific reports · 2020Article
- Compensatory Hippocampal Recruitment Supports Preserved Episodic Memory in Autism Spectrum Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Adolescents at clinical high risk for psychosis show qualitatively altered patterns of activation during rule learning.NeuroImage. Clinical · 2020Article
- Thinking fast or slow? Functional magnetic resonance imaging reveals stronger connectivity when experienced neurologists diagnose ambiguous cases.Brain communications · 2020Article
- Distinct and opposite profiles of connectivity during self-reference task and rest in youth at clinical high risk for psychosis.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Self-reference is impaired in psychotic disorders such as schizophrenia, associated with disability, and closely related to characteristic patterns of aberrant brain connectivity. However, at present, it is unclear whether self-reference is impacted in pathogenesis of the disorder. Alterations in connectivity during a self-reference task or resting-state in the psychosis risk (i.e., prodromal) period may yield important clues for biomarker development, as well as for novel treatment targets. This study examined a task-based and resting-state functional magnetic resonance imaging in individuals at clinical high risk (CHR) for psychosis (n = 22) and healthy control unaffected peers (n = 20). The self-reference task comprised three task conditions where subjects were asked if an adjective was relevant to themselves (self), a designated other individual (other), or to evaluate the word's spelling (letter). Connectivity analyses examined medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC), regions commonly found in conjunction analyses of self-reference, during both the self-reference task and rest. In task connectivity analyses, CHR individuals exhibited decreased mPFC-PCC connectivity when compared to controls. In resting-state analyses, CHR participants showed greater mPFC-PCC connectivity. Taken together, results suggest that psychosis-like alterations in mPFC-PCC connectivity is present prior to psychosis onset across both task and rest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.