Evidence map›Paper›PMID 30941842›Full record

ReviewIUBMB life2019

Thinking outside of the cell: Secreted protein kinases in bacteria, parasites, and mammals.

Brenden C Park, Michael Reese, Vincent S Tagliabracci

Open access · bronzeAbstract readReview
In one paragraph

Review in IUBMB life, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Inactivation mechanisms of NaCommunications biology · 2025
    Article
  3. Article
  4. Editorial: Reviews in microbial pathogenesis.Frontiers in microbiology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. TheProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  10. AThe Journal of biological chemistry · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brenden C ParkDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Michael ReeseDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Vincent S TagliabracciDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9735-4678
The University of Texas Southwestern Medical Center · US

Funding

Phosphorylation of FGF23 coordinates crosstalk between the skeleton and kidneyR00DK099254 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI TAGLIABRACCI, VINCENT SCOTT · 2015 to 2017
$746k
NIDDK NIH HHS R00 DK099254NIH HHS R00DK099254
6 · The paper itself

Abstract

Previous decades have seen an explosion in our understanding of protein kinase function in human health and disease. Hundreds of unique kinase structures have been solved, allowing us to create generalized rules for catalysis, assign roles of communities within the catalytic core, and develop specific drugs for targeting various pathways. Although our understanding of intracellular kinases has developed at a fast rate, our exploration into extracellular kinases has just begun. In this review, we will cover the secreted protein kinase families found in humans, bacteria, and parasites. © 2019 IUBMB Life, 71(6):749-759, 2019.

Indexed as

AnimalsBacteriaBiological TransportHumansMammalsParasitesPhosphorylationProtein KinasesSubstrate SpecificityProtein Kinasesbacterial effectorsFam20Cparasite kinasesprotein kinasessecretory pathway

Identifiers

PMID30941842
PMCPMC7967855
OpenAlexW2933917006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.