Evidence map›Paper›PMID 30941774›Full record

ArticleClinical cardiology2019

Wake Forest University long-term follow-up of type 2 myocardial infarction: The Wake-Up T2MI Registry.

Hanumantha R Jogu, Sameer Arora, Muthiah Vaduganathan, Arman Qamar, Ambarish Pandey, Parag A Chevli, Tusharkumar H Pansuriya, Muhammad I Ahmad, Abhishek Dutta, Padageshwar R Sunkara and 6 more

Abstract read
In one paragraph

Article in Clinical cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hanumantha R JoguDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID https://orcid.org/0000-0001-9965-9638
Sameer AroraDivision of Cardiology, University of North Carolina, Chapel Hill, North Carolina.ORCID https://orcid.org/0000-0002-6387-3015
Muthiah VaduganathanBrigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Massachusetts.
Arman QamarBrigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Massachusetts.
Ambarish PandeyDepartment of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Parag A ChevliDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID https://orcid.org/0000-0002-4084-8175
Tusharkumar H PansuriyaDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Muhammad I AhmadDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID https://orcid.org/0000-0002-6870-1722
Abhishek DuttaDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Padageshwar R SunkaraDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Waqas QureshiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Massachusetts School of Medicine, Worcester, Massachusetts.
Sujethra VasuSection on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Bharathi UpadhyaSection on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Deepak L BhattBrigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, Massachusetts.ORCID https://orcid.org/0000-0002-1278-6245
James L JanuzziCardiology Division, Massachusetts General Hospital, and Cardiometabolic Trials, Baim Institute for Clinical Research, Boston, Massachusetts.ORCID https://orcid.org/0000-0002-8338-1798
David HerringtonSection on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
TRAINING PROGRAM IN CARDIOVASCULAR RESEARCHT32HL007604 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARK W FEINBERG · 1985 to 2026
$19.0M
American Heart Association Strategically Focused Research Network in Vascular Disease 18SFRN3390085NCATS NIH HHS UL1 TR002541NHLBI NIH HHS T32 HL007604NHLBI T32 T32HL007604NIH/NCATS UL 1TR002541
6 · The paper itself

Abstract

backgroundThe Wake-Up T2MI Registry is a retrospective cohort study investigating patients with type 2 myocardial infarction (T2MI), acute myocardial injury, and chronic myocardial injury. We aim to explore risk stratification strategies and investigate clinical characteristics, management, and short- and long-term outcomes in this high-risk, understudied population.

methodsFrom 1 January 2009 to 31 December 2010, 2846 patients were identified with T2MI or myocardial injury defined as elevated cardiac troponin I with at least one value above the 99th percentile upper reference limit and coefficient of variation of 10% (>40 ng/L) and meeting our inclusion criteria. Data of at least two serial troponin values will be collected from the electronic health records to differentiate between acute and chronic myocardial injury. The Fourth Universal Definition will be used to classify patients as having (a) T2MI, (b) acute myocardial injury, or (c) chronic myocardial injury during the index hospitalization. Long-term mortality data will be collected through data linkage with the National Death Index and North Carolina State Vital Statistics.

resultsWe have collected data for a total of 2205 patients as of November 2018. The mean age of the population was 65.6 ± 16.9 years, 48% were men, and 64% were white. Common comorbidities included hypertension (71%), hyperlipidemia (35%), and diabetes mellitus (30%). At presentation, 40% were on aspirin, 38% on β-blockers, and 30% on statins.

conclusionImproved characterization and profiling of this cohort may further efforts to identify evidence-based strategies to improve cardiovascular outcomes among patients with T2MI and myocardial injury.

Indexed as

Disease ManagementElectrocardiographyHospitals, UniversityAgedCoronary AngiographyFemaleFollow-Up StudiesHospital MortalityHumansMaleMyocardial InfarctionNorth CarolinaPrognosisRegistriesRetrospective StudiesSeverity of Illness Indexacute myocardial injurychronic myocardial injurydemand ischemiamyonecrosistroponintype 2 myocardial infarction

Identifiers

PMID30941774
PMCPMC6553563

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.