ArticleBioMed research international2019
Clinical Characteristics of 1378 Inpatients with Spinal Tuberculosis in General Hospitals in South-Central China.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Maternal and fetal outcomes of spinal tuberculosis in pregnancy: A systematic review and descriptive pooled analysis.Neurosurgical review · 2026Pooled it
- Bone and joint tuberculosis: clinical manifestation, diagnostic techniques and drug resistance analysis.Frontiers in cellular and infection microbiology · 2025Article
- Thoracic Paravertebral Dedifferentiated Liposarcoma Masquerading as Spinal Tuberculosis: Case Report and Review of Literature.Case reports in radiology · 2025Article
- Bone features reinforce differential diagnosis between tuberculous spondylitis and brucellosis spondylitis.BMC infectious diseases · 2024Article
- Multifocal Skeletal Tuberculosis - A Case Report.Journal of orthopaedic case reports · 2024Article
- Analysis on the epidemiological and drug resistance characteristics of osteoarticular tuberculosis in South-central China.Frontiers in public health · 2024Article
- Advances of Long Non-Coding RNAs as Potential Biomarkers for Tuberculosis: New Hope for Diagnosis?Pharmaceutics · 2023Review
- Intraspinal and Intracranial Neurotuberculosis, Clinical and Imaging Characteristics and Outcomes in Hospitalized Patients: A Cohort Study (2000-2022).Journal of clinical medicine · 2023Article
- Spinal Tuberculosis: Features and Early Predictive Factors of Poor Outcomes.Mediterranean journal of rheumatology · 2023Article
- Tuberculosis of the spine.World journal of orthopedics · 2023Review
- A high proportion of caseous necrosis, abscess, and granulation tissue formation in spinal tuberculosis.Frontiers in microbiology · 2023Article
- Comparative efficacy of traditional conservative treatment and CT-guided local chemotherapy for mild spinal tuberculosis.BMC musculoskeletal disorders · 2022Article
- Epidemiological Insights from 1,652 Patients with Spinal Tuberculosis Managed at a Single Center: A Retrospective Review of 5-Year Data.Asian spine journal · 2022Article
- Spinous Process Combined With a Titanium Mesh Cage as a Bone Graft in the Stability Reconstruction of Lumbar or Lumbosacral Spinal Tuberculosis.Frontiers in surgery · 2022Article
- Expression and Clinical Significance of lncRNA NEAT1 in Patients with Spinal Tuberculosis.Disease markers · 2022Article
- Analysis of Clinical Characteristics of 556 Spinal Tuberculosis Patients in Two Tertiary Teaching Hospitals in Guangxi Province.BioMed research international · 2021Article
- Posterior-only vs. combined posterior-anterior approaches in treating lumbar and lumbosacral spinal tuberculosis: a retrospective study with minimum 7-year follow-up.Journal of orthopaedic surgery and research · 2020Article
- One-stage posterior debridement, bone grafting fusion, and mono-segment vs. short-segment fixation for single-segment lumbar spinal tuberculosis: minimum 5-year follow-up outcomes.BMC musculoskeletal disorders · 2020Article
- Multi-drug resistant spinal tuberculosis-epidemiological characteristics of in-patients: a multicentre retrospective study.Epidemiology and infection · 2020Observational
- Analysis of Clinical Factors, Bacterial Genotyping, and Drug Resistance for Spinal Tuberculosis in South-Central China.BioMed research international · 2020Article
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11 authors at 1 institution in 1 country.
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Abstract
In this retrospective study, charts of inpatients with spinal tuberculosis (STB) treated in large-scale general hospitals in Changsha, Hunan, China, between 2007 and 2016 were reviewed to investigate their clinical characteristics. Demographic, epidemiological and clinical features, imaging findings, treatment methods, and prognosis were summarized and analyzed. There were 1378 patients, 805 males and 573 females, with a mean age of 43.7 years. The mean interval between symptom onset and diagnosis was 16.0 months (range 15 days-240 months). The incidence of back pain, radicular pain and symptoms of systemic toxicity was 92.5%, 40.1%, and 32.1%, respectively. The rate of neurological impairment was 49.9 %. STB was present in two or more vertebrae in 91.1% of patients, with two adjacent vertebrae being involved in 67.9% of them. The lumbar segment (38.2%) was the most frequently affected, followed by the thoracic spine (35.7%). The sacrococcygeal area was the least frequently involved (0.8%). Abscesses were detected in 65.5% of patients. One thousand patients (72.6%) were managed with surgery and 378 (27.4%) with anti-TB drugs only. Cure was achieved in 1215 patients (88.2%), whereas 49 (3.5 %) had relapses. Concomitant pulmonary TB (PTB) was diagnosed in 366 patients (26.6%) and 63 (4.6%) had concomitant diabetes. Compared with the previous five years, the number of older patients, urban patients, and medical staff with STB had increased by 6.1%, 5.2%, and 1.3%, respectively in the five years studied. STB remains a severe public health problem that cannot be ignored. Most of the patients ignored early symptoms and therefore received untimely treatment. Thus, surveillance for and treatment of STB in South-central China requires strengthening. In addition to the current China-wide database of patients with PTB, a China-wide database of patients with STB should also be set up.
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