Evidence map›Paper›PMID 30941370›Full record

ArticleBioMed research international2019

The Effect of Butyrate-Supplemented Parenteral Nutrition on Intestinal Defence Mechanisms and the Parenteral Nutrition-Induced Shift in the Gut Microbiota in the Rat Model.

Zuzana Jirsova, Marie Heczkova, Helena Dankova, Hana Malinska, Petra Videnska, Hana Vespalcova, Lenka Micenkova, Lenka Bartonova, Eva Sticova, Alena Lodererova and 4 more

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Farnesoid X Receptor Agonist Tropifexor Improves Intestinal Defense Response and Epithelial Barrier Function in Neonatal Piglets Receiving Parenteral Nutrition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Butyrate: More Than a Short Chain Fatty Acid.Current nutrition reports · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. The role of butyrate in surgical and oncological outcomes in colorectal cancer.American journal of physiology. Gastrointestinal and liver physiology · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Zuzana JirsovaDepartment of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague 4-140 21, Czech Republic.
Marie HeczkovaDepartment of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague 4-140 21, Czech Republic.
Helena DankovaDepartment of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague 4-140 21, Czech Republic.
Hana MalinskaDepartment of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague 4-140 21, Czech Republic.
Petra VidenskaRECETOX, Faculty of Science, Masaryk University, Brno 625 00, Czech Republic.
Hana VespalcovaRECETOX, Faculty of Science, Masaryk University, Brno 625 00, Czech Republic.
Lenka MicenkovaRECETOX, Faculty of Science, Masaryk University, Brno 625 00, Czech Republic.
Lenka BartonovaClinical and Transplant Pathology Department, Institute for Clinical and Experimental Medicine, Prague 4-140 21, Czech Republic.
Eva SticovaClinical and Transplant Pathology Department, Institute for Clinical and Experimental Medicine, Prague 4-140 21, Czech Republic.ORCID 0000-0003-2486-6266
Alena LodererovaClinical and Transplant Pathology Department, Institute for Clinical and Experimental Medicine, Prague 4-140 21, Czech Republic.
Lucia PrefertusováClinical and Transplant Pathology Department, Institute for Clinical and Experimental Medicine, Prague 4-140 21, Czech Republic.
Alena SekerkovaPrevedig, Prague 1-110 00, Czech Republic.
Jaromir HradeckyFaculty of Forestry and Wood Sciences, Czech University of Life Sciences, Prague, Czech Republic.
Monika CahovaDepartment of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague 4-140 21, Czech Republic.ORCID 0000-0003-2640-5084
Institute of Clinical and Experimental Medicine · CZMasaryk University · CZCzech University of Life Sciences Prague · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Butyrate produced by the intestinal microbiota is essential for proper functioning of the intestinal immune system. Total dependence on parenteral nutrition (PN) is associated with numerous adverse effects, including severe microbial dysbiosis and loss of important butyrate producers. We hypothesised that a lack of butyrate produced by the gut microbiota may be compensated by its supplementation in PN mixtures. We tested whether

Indexed as

Dietary SupplementsGastrointestinal MicrobiomeParenteral NutritionAnimalsBiodiversityButyratesColonGene Expression RegulationIleumIntestinesIntestine, SmallLymph NodesLymphocytesMaleModels, AnimalMucinsButyratesMucinsPeptidesRNA, MessengerTight Junction Proteins

Identifiers

PMID30941370
PMCPMC6421034
OpenAlexW2896897964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.