Evidence map›Paper›PMID 30941365›Full record

ArticleBioMed research international2019

Evaluation of the Immunogenicity of a Vascular Graft Covered with Collagen Derived from the European Carp (

Lukas Lambert, Michaela Novakova, Peter Lukac, Dana Cechova, Lenka Sukenikova, Jiri Hrdy, Mikulas Mlcek, Hynek Chlup, Tomas Suchy, Tomas Grus

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  6. Article
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  8. Article
  9. Protein-Based 3D Biofabrication of Biomaterials.Bioengineering (Basel, Switzerland) · 2021
    Review
  10. Vancomycin-releasing cross-linked collagen sponges as wound dressings.Bosnian journal of basic medical sciences · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lukas LambertDepartment of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic.ORCID 0000-0003-2299-4707
Michaela NovakovaInstitute of Immunology and Microbiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studnickova 7, 128 00 Prague 2, Czech Republic.
Peter LukacDepartment of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic.
Dana CechovaInstitute of Immunology and Microbiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studnickova 7, 128 00 Prague 2, Czech Republic.
Lenka SukenikovaInstitute of Immunology and Microbiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studnickova 7, 128 00 Prague 2, Czech Republic.
Jiri HrdyInstitute of Immunology and Microbiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Studnickova 7, 128 00 Prague 2, Czech Republic.
Mikulas MlcekInstitute of Physiology, First Faculty of Medicine, Charles University in Prague, Albertov 5, 128 00, Prague 2, Czech Republic.
Hynek ChlupDepartment of Mechanics, Biomechanics and Mechatronics, Faculty of Mechanical Engineering, Czech Technical University in Prague, Technicka 4, 166 07 Prague 6, Czech Republic.
Tomas SuchyInstitute of Rock Structure and Mechanics of the Czech Academy of Sciences, V Holesovickach 41, 182 09, Prague 8, Czech Republic.
Tomas GrusDepartment of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic.
Charles University · CZCzech Academy of Sciences, Institute of Rock Structure and Mechanics · CZCzech Technical University in Prague · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess the systemic and local immunological response to subcutaneous implants of a vascular graft covered with collagen extracted from the European carp (freshwater fish) or with collagen of bovine origin.

methodsPieces of a vascular graft covered by pure bovine (Bos taurus, BOV, n=14) or carp (Cyprinus carpio, CYP, n=14) collagen 5 mm in size were implanted subcutaneously in the dorsum of a Balb/cOla mice. A sham operation group of 12 animals served as the control. At 7 and 14 days after the operation, one-half of each group was terminated and blood for serum, spleen, and implant with surrounding tissue were collected. Mean cytokine (TNF-

resultsWe found no significant difference among control, BOV, and CYP groups in mean cytokine serum levels at seven days. At day 14, the BOV group had higher levels of TNF-

conclusionsImplants covered with carp collagen induce an immunological response that is comparable to that of bovine collagen covered implants in a mouse model.

Indexed as

Blood Vessel ProsthesisAnimalsCarpsCattleCell ProliferationCellular MicroenvironmentCollagenCytokinesMice, Inbred BALB CRNA, MessengerSpleenCollagenCytokinesRNA, Messenger

Identifiers

PMID30941365
PMCPMC6420978
OpenAlexW2916219180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.