Evidence map›Paper›PMID 30941323›Full record

ArticleAnnals of surgical treatment and research2019

Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis.

Hyunjung Kim, Hae Il Jung, Soon Ha Kwon, Sang Ho Bae, Hyung Chul Kim, Moo-Jun Baek, Moon Soo Lee

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical treatment and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  18. Detection of circulatingFrontiers in oncology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hyunjung KimDepartment of Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Hae Il JungDepartment of Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Soon Ha KwonDepartment of Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Sang Ho BaeDepartment of Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Hyung Chul KimDepartment of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
Moo-Jun BaekDepartment of Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Moon Soo LeeDepartment of Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.ORCID https://orcid.org/0000-0002-3955-1331
Soonchunhyang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRecently, the neutrophil-to-lymphocyte ratio (NLR), an inflammatory response marker, has been reported to be associated with the prognosis in patients with various type of cancer. However, there have been no studies until now that have explored the prognostic role of combined detection of NLR and CEA in patients with synchronous liver-limited colorectal metastases (sCRLM).

methodsEighty-three patients who histologically diagnosed as sCRLM were selected. Their laboratory and clinical data were collected retrospectively. Using receiver operating characteristic curve analysis, the cutoff value of NLR was calculated based on which patients were assigned to a high NLR (more than 1.94) group and low NLR (less than 1.94) group. A cutoff value of 100 ng/mL for serum CEA level was used in light of the previous literature.

resultsCEA level and Poorly differentiated histology of colon cancer was significantly correlated with high NLR (P = 0.005 and P = 0.048, respectively). The multivariate analysis identified the high NLR as independent prognostic factors for OS and DFS in all patients (P = 0.010 and P = 0.006, respectively). Patients with both low levels of NLR and CEA had a significantly longer OS and DFS (P = 0.026 and P = 0.009, respectively).

conclusionIn conclusion, elevated preoperative NLR is strongly correlated with both survival and recurrence in patients who have been diagnosed with resectable sCRLM. The combination of NLR and CEA level could be a more powerful prognostic marker than NLR alone.

Indexed as

Carinoembryonic antigenColonic neoplasmsLiverMetastasisNeutrophilsPrognosis

Identifiers

PMID30941323
PMCPMC6444047
OpenAlexW2931934869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.