ArticleJournal of breast cancer2019
Determining Whether High Nodal Burden in Early Breast Cancer Patients Can Be Predicted Preoperatively to Avoid Sentinel Lymph Node Biopsy.
Article in Journal of breast cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prediction of sentinel lymph node status in patients with early breast cancer using breast imaging as an alternative to surgical staging-a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Less is more: the role of preoperative ultrasound as a risk stratifying tool in identifying low volume axillary disease in breast cancer.The British journal of radiology · 2026Observational
- Preoperative Axillary Ultrasound in the Era of Z0011: A Model for Predicting High Axillary Disease Burden.Current oncology (Toronto, Ont.) · 2025Article
- Risking arm lymphedema in more than a hundred patients to benefit one patient-is it worth it?Gland surgery · 2025Article
- Preoperative MRI Features Associated With Axillary Nodal Burden and Disease-Free Survival in Patients With Early-Stage Breast Cancer.Korean journal of radiology · 2024Article
- Use of axillary ultrasound to guide breast cancer management in the genomic assay era.Breast disease · 2024Article
- Axillary management of breast cancer patients with isolated chest wall recurrence after mastectomy.Annals of translational medicine · 2023Article
- Non-invasive predictors of axillary lymph node burden in breast cancer: a single-institution retrospective analysis.Breast cancer research and treatment · 2022Article
- Determining the benefit of neoadjuvant chemotherapy in reduction of axillary dissection rates in Z0011 trial cohort with high nodal burden.Gland surgery · 2022Article
- Prediction of high nodal burden in invasive breast cancer by quantitative shear wave elastography.Quantitative imaging in medicine and surgery · 2022Article
- Article
- Would Removal of All Ultrasound Abnormal Metastatic Lymph Nodes Without Sentinel Lymph Node Biopsy Be Accurate in Patients with Breast Cancer with Neoadjuvant Chemotherapy?The oncologist · 2020Article
- Axillary ultrasound during neoadjuvant systemic therapy in triple-negative breast cancer patients.European journal of radiology · 2020Article
- Sentinel Node Biopsy in Early Breast Cancer Patients with Palpable Axillary Node.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Mode of presentation and skin thickening on ultrasound may predict nodal burden in breast cancer patients with a positive axillary core biopsy.The British journal of radiology · 2020Article
- Predictors of Neoadjuvant Chemotherapy Response in Breast Cancer: A Review.OncoTargets and therapy · 2020Review
- Can We Identify or Exclude Extensive Axillary Nodal Involvement in Breast Cancer Patients Preoperatively?Journal of oncology · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe Z0011 trial showed that axillary lymph node dissection (ALND) can be safely avoided in breast cancer patients with low nodal burden (LNB). ALND can be performed in patients with high nodal burden (HNB). We aimed to determine whether HNB in early breast cancer patients can be predicted preoperatively to avoid sentinel lymph node biopsy (SLNB).
methodsEarly invasive breast cancer patients (cT1-2cN0) were retrospectively reviewed. We excluded patients with neoadjuvant chemotherapy and incomplete data. The patients were divided into the following groups based on surgical histology: no positive (N0), LNB, and HNB, defined as 0, 1-2, and ≥ 3 metastatic lymph nodes (LNs), respectively. Of the patients with metastatic nodal disease, only those with ALND were included in the analysis. Clinical, radiological, and histological parameters were evaluated using logistic regression analysis as predictors of HNB versus LNB and N0 combined.
resultsOf the 1,298 included patients, 832 (64.1%), 286 (22.0%), and 180 (13.9%) had N0, LNB, and HNB, respectively. Univariate logistic regression analysis revealed that sonographic features of breast tumor size (
conclusionThe detection of ≥ 4 abnormal LNs on ultrasound can help to identify HNB patients who require upfront ALND and thus avoid SLNB.
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