Evidence map›Paper›PMID 30941204›Full record

ReviewF1000Research2019

The Application of Omics Technologies to Study Axon Regeneration and CNS Repair.

Andrea Tedeschi, Phillip G Popovich

Open access · goldAbstract readReview
In one paragraph

Review in F1000Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The stem cell markerProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  5. Neuronal αPflugers Archiv : European journal of physiology · 2020
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Andrea TedeschiDepartment of Neuroscience and Discovery Themes Initiative, College of Medicine, Ohio State University, Columbus, Ohio, 43210, USA.ORCID 0000-0002-9165-8013
Phillip G PopovichCenter for Brain and Spinal Cord Repair, Institute for Behavioral Medicine Research, Ohio State University, Columbus, Ohio, 43210, USA.ORCID 0000-0003-1329-7395
Institute for Behavioral Medicine · USThe Ohio State University · US

Funding

Preventing autonomic dysreflexia to restore immune function after SCIR01NS083942 · NINDS · OHIO STATE UNIVERSITY · PI POPOVICH, PHILLIP G · 2014 to 2018
$2.2M
Role of the spinal cord - gut - immune axis after spinal cord injuryR01NS099532 · NINDS · OHIO STATE UNIVERSITY · PI POPOVICH, PHILLIP G · 2017 to 2018
$1.0M
Glucocorticoids and sensory neuron plasticityR01NS094566 · NINDS · OHIO STATE UNIVERSITY · PI POPOVICH, PHILLIP G · 2017 to 2018
$828k
NINDS NIH HHS R01 NS083942NINDS NIH HHS R01 NS094566NINDS NIH HHS R01 NS099532
6 · The paper itself

Abstract

Traumatic brain and spinal cord injuries cause permanent disability. Although progress has been made in understanding the cellular and molecular mechanisms underlying the pathophysiological changes that affect both structure and function after injury to the brain or spinal cord, there are currently no cures for either condition. This may change with the development and application of multi-layer omics, new sophisticated bioinformatics tools, and cutting-edge imaging techniques. Already, these technical advances, when combined, are revealing an unprecedented number of novel cellular and molecular targets that could be manipulated alone or in combination to repair the injured central nervous system with precision. In this review, we highlight recent advances in applying these new technologies to the study of axon regeneration and rebuilding of injured neural circuitry. We then discuss the challenges ahead to translate results produced by these technologies into clinical application to help improve the lives of individuals who have a brain or spinal cord injury.

Indexed as

AxonsComputational BiologySpinal Cord InjuriesGenomicsHumansNerve RegenerationProteomicsaxon regenerationbrain injuryepigenomicskinomicsmetagenomicsphosphoproteomicsspinal cord injurytranscriptomics

Identifiers

PMID30941204
PMCPMC6429978
OpenAlexW2925319412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.