Evidence map›Paper›PMID 30941121›Full record

ArticleFrontiers in immunology2019

Adipose Tissue in Persons With HIV Is Enriched for CD4

Celestine N Wanjalla, Wyatt J McDonnell, Louise Barnett, Joshua D Simmons, Briana D Furch, Morgan C Lima, Beverly O Woodward, Run Fan, Ye Fei, Paxton G Baker and 7 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04451980 (The HIV, Adipose Tissue Immunology, and Metabolism Study), which is not on this map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04451980 completednot on this map

The HIV, Adipose Tissue Immunology, and Metabolism Study

TypeobservationalSponsorVanderbilt University Medical CenterRan2017 to 2026Enrolled172ConditionsHiv, Diabetes Mellitus, Type 2ArmsSubcutaneous adipose tissue biopsy, CT scan, Oral glucose tolerance test, Blood collection
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Review
  3. Adhesion G protein-coupled receptors.Pharmacological reviews · 2026
    Review
  4. Review
  5. Review
  6. Mapping CMV-related immune signatures in blood, aorta and perivascular mediastinal adipose tissue.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Mouse Models of HIV-Associated Atherosclerosis.International journal of molecular sciences · 2025
    Review
  11. Observational
  12. Article
  13. Article
  14. Review
  15. CD3bioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Review
  18. CD4Frontiers in immunology · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Celestine N WanjallaDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Wyatt J McDonnellDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Louise BarnettTennessee Center for AIDS Research, Vanderbilt University Medical Center, Nashville, TN, United States.
Joshua D SimmonsTennessee Center for AIDS Research, Vanderbilt University Medical Center, Nashville, TN, United States.
Briana D FurchDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Morgan C LimaDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Beverly O WoodwardDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Run FanDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States.
Ye FeiDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States.
Paxton G BakerVANTAGE, Vanderbilt University Medical Center, Nashville, TN, United States.
Ramesh RamInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, Australia.
Mark A PilkintonDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Mona MashayekhiDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Nancy J BrownDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Simon A MallalDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Spyros A KalamsDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
John R KoetheDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Vanderbilt University Medical Center · USMurdoch University · AUVanderbilt University · US

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Koethe · 2015 to 2026
$27.5M
Vanderbilt Infection Pathogenesis and Epidemiology Research Training ProgramT32AI007474 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KALAMS, SPYROS A · 1995 to 2025
$6.9M
The Role of Adipose-Resident T Cells in HIV-Associated Glucose IntoleranceR01DK112262 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KOETHE, JOHN · 2017 to 2021
$3.8M
Innate and Adaptive Immunity in HIV-associated Impaired Glucose Tolerance and DiabetesR56DK108352 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KOETHE, JOHN · 2015 to 2016
$979k
NCRR NIH HHS UL1 RR024975NIAID NIH HHS P30 AI110527NIAID NIH HHS T32 AI007474NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK112262NIDDK NIH HHS R56 DK108352
6 · The paper itself

Abstract

Chronic T cell activation and accelerated immune senescence are hallmarks of HIV infection, which may contribute to the increased risk of cardiometabolic diseases in people living with HIV (PLWH). T lymphocytes play a central role in modulating adipose tissue inflammation and, by extension, adipocyte energy storage and release. Here, we assessed the CD4

Indexed as

Adipose TissueAdultAntigens, CDAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesCD57 AntigensCD69 AntigensCX3C Chemokine Receptor 1FemaleGlucose IntoleranceHIV InfectionsHumansImmunologic MemoryLectins, C-TypeMaleMiddle AgedADGRG1 protein, humanAntigens, CDAntigens, Differentiation, T-LymphocyteCD57 AntigensCD69 AntigensCX3C Chemokine Receptor 1CX3CR1 protein, humanLectins, C-TypeReceptors, G-Protein-Coupledadipose tissueCX3CR1diabetes mellitusGPR56HIV—human immunodeficiency virusmemory T cellsT effector memory cellsTEMRA

Identifiers

PMID30941121
PMCPMC6433850
OpenAlexW2923258631

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.