ReviewFrontiers in microbiology2019
Oxidant-Sensing Pathways in the Responses of Fungal Pathogens to Chemical Stress Signals.
Review in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- The transcription factor AP-1 regulates the catalase family and oxidative stress adaptation in the dermatophyte Trichophyton rubrum.Scientific reports · 2026Article
- Molecular frontiers of fungal autophagy: from molecular mechanisms to potential targets for antifungal drug discovery.World journal of microbiology & biotechnology · 2026Review
- A ZnCommunications biology · 2025Article
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- Modulation ofInternational journal of molecular sciences · 2025Article
- Type 2C Protein Phosphatase MoPtc6 Plays Critical Roles in the Development and Virulence ofJournal of fungi (Basel, Switzerland) · 2025Article
- The Effects of Marine Fungal Asterripeptides A-C on In Vitro and In VivoPharmaceuticals (Basel, Switzerland) · 2024Article
- Unveiling the super tolerance ofMicrobiology spectrum · 2024Article
- PeAP1-mediated oxidative stress response plays an important role in the growth and pathogenicity ofMicrobiology spectrum · 2023Article
- The oxidative aging model integrated various risk factors in type 2 diabetes mellitus at system level.Frontiers in endocrinology · 2023Article
- A simplified and easy-to-use HIP HOP assay provides insights into chalcone antifungal mechanisms of action.FEBS letters · 2022Article
- The Anti-Fungal Activity of Nitropropenyl Benzodioxole (NPBD), a Redox-Thiol Oxidant and Tyrosine Phosphatase Inhibitor.Antibiotics (Basel, Switzerland) · 2022Article
- The bZIP Ap1 transcription factor is a negative regulator of virulence attributes of the anthropophilic dermatophyteCurrent research in microbial sciences · 2022Article
- Transcription factor control of virulence in phytopathogenic fungi.Molecular plant pathology · 2021Review
- The Antiaging Effect of Active Fractions andAntioxidants (Basel, Switzerland) · 2020Article
- The PAC-3 transcription factor critically regulates phenotype-associated genes in Neurospora crassa.Genetics and molecular biology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Host defenses expose fungal pathogens to oxidants and antimicrobial chemicals. The fungal cell employs conserved eukaryotic signaling pathways and dedicated transcription factors to program its response to these stresses. The oxidant-sensitive transcription factor of yeast, YAP1, and its orthologs in filamentous fungi, are central to tolerance to oxidative stress. The C-terminal domain of YAP1 contains cysteine residues that, under oxidizing conditions, form an intramolecular disulfide bridge locking the molecule in a conformation where the nuclear export sequence is masked. YAP1 accumulates in the nucleus, promoting transcription of genes that provide the cell with the ability to counteract oxidative stress. Chemicals including xenobiotics and plant signals can also promote YAP1 nuclearization in yeast and filamentous fungi. This could happen via direct or indirect oxidative stress, or by a different biochemical pathway. Plant phenolics are known antioxidants, yet they have been shown to elicit cellular responses that would usually be triggered to counter oxidant stress. Here we will discuss the evidence that YAP1 and MAPK pathways respond to phenolic compounds. Following this and other examples, we explore here how oxidative-stress sensing networks of fungi might have evolved to detect chemical stressors. Furthermore, we draw functional parallels between fungal YAP1 and mammalian Keap1-Nrf2 signaling systems.
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