Evidence map›Paper›PMID 30941094›Full record

ArticleFrontiers in neurology2019

Treating Disorders of Consciousness With Apomorphine: Protocol for a Double-Blind Randomized Controlled Trial Using Multimodal Assessments.

Leandro R D Sanz, Nicolas Lejeune, Séverine Blandiaux, Estelle Bonin, Aurore Thibaut, Johan Stender, Neal M Farber, Ross D Zafonte, Nicholas D Schiff, Steven Laureys and 1 more

2 registry-linked trialsOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05213169 phase2 / phase3recruitingnot on this mapstarted 2021, after this paper: background citation

Randomized Controlled Trial of Apomorphine in Severe Brain-injured Patients: a Double-blind Behavioral and Neuroimaging Study

TypeinterventionalSponsorUniversity of LiegeRan2021 to 2026Enrolled48ConditionsDisorder of ConsciousnessArmsApomorphine Hydrochloride 5mg/ml, Sodium chloride 9mg/ml
NCT06939348 narecruitingnot on this mapstarted 2025, after this paper: background citation

Safety and Efficacy of Thalamic Focused Ultrasound Stimulation (tFUS) for Promoting Recovery After Severe Traumatic Brain Injury

TypeinterventionalSponsorUniversity of California, Los AngelesRan2025 to 2028Enrolled60ConditionsConsciousness Disorders, Disorders of Consciousness Due to Severe Brain InjuryArmsThe Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Brain health: A concern for anaesthesiologists and intensivists.European journal of anaesthesiology and intensive care · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Leandro R D SanzGIGA Consciousness, University of Liège, Liège, Belgium.
Nicolas LejeuneGIGA Consciousness, University of Liège, Liège, Belgium.
Séverine BlandiauxGIGA Consciousness, University of Liège, Liège, Belgium.
Estelle BoninGIGA Consciousness, University of Liège, Liège, Belgium.
Aurore ThibautGIGA Consciousness, University of Liège, Liège, Belgium.
Johan StenderDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.
Neal M FarberNeuroHealing Pharmaceuticals Inc., Newton, MA, United States.
Ross D ZafonteDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, United States.
Nicholas D SchiffFeil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, United States.
Steven LaureysGIGA Consciousness, University of Liège, Liège, Belgium.
Olivia GosseriesGIGA Consciousness, University of Liège, Liège, Belgium.
University of Liège · BEMassachusetts General Hospital · USMIND Research Institute · USNeuroHealing Pharmaceuticals (United States) · USUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

apomorphineclinical trialdisorders of consciousnessdopaminemesocircuitminimally conscious stateprotocolunresponsive wakefulness syndrome

Identifiers

PMID30941094
PMCPMC6433751
OpenAlexW2923444373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.