Evidence map›Paper›PMID 30941085›Full record

ReviewFrontiers in neurology2019

Parkinson's Disease and the Environment.

Nicole Ball, Wei-Peng Teo, Shaneel Chandra, James Chapman

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 226 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 7 pooled it
32.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05677529 unknown statusnot on this mapstarted 2021, after this paper: background citation

Prodromal and Overt Parkinson's Disease Epidemiological Study in Brazil

TypeobservationalSponsorHospital de Clinicas de Porto AlegreRan2021 to 2025Enrolled8,000ConditionsParkinson Disease, Parkinsonism
NCT05759403 unknown statusnot on this mapstarted 2022, after this paper: background citation

Comparative Study Between Parkinson's Disease and Parkinson Dementia Complex : Genetics, Clinical, Neurophysiological

TypeobservationalSponsorAssiut UniversityRan2022 to 2023Enrolled40ConditionsParkinson Disease Dementia, Parkinson DiseaseArmsCortical excitability using transcranial magnetic stimulation
3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 7 syntheses or guidelines pooled it, 468 citations in OpenAlex.

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  14. Genetic and environmental risk factors of Parkinsonism.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Nicole BallSchool of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, QLD, Australia.
Wei-Peng TeoSchool of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition, Deakin University, Melbourne, VIC, Australia.
Shaneel ChandraSchool of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, QLD, Australia.
James ChapmanSchool of Science, RMIT University, Melbourne, VIC, Australia.
Central Queensland University · AUDeakin University · AURMIT University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder that affects an estimated 10 million sufferers worldwide. The two forms of PD include familial and sporadic, and while the etiology of PD is still largely unknown, the condition is likely to be multifactorial with genetic and environmental factors contributing to disease genesis. Diagnosis of the condition is attained through the observation of cardinal clinical manifestations including resting tremor, muscle rigidity, slowness or loss of movement, and postural instability. Unfortunately, by the time these features become apparent extensive neurological damage has already occurred. A cure for PD has not been identified and the current therapy options are pharmaceutical- and/or surgical-based interventions to treat condition symptoms. There is no specific test for PD and most diagnoses are confirmed by a combination of clinical symptoms and positive responses to dopaminergic drug therapies. The prevalence and incidence of PD vary worldwide influenced by several factors such as age, gender, ethnicity, genetic susceptibilities, and environmental exposures. Here, we will present environmental factors implicated in sporadic PD onset. By understanding the mechanisms in which environmental factors interact with, and affect the brain we can stride toward finding the underlying cause(s) of PD.

Indexed as

demographicalenvironmentalheavy metalsillicit drugsParkinson's diseasepesticides

Identifiers

PMID30941085
PMCPMC6433887
OpenAlexW2924267298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.