Evidence map›Paper›PMID 30941062›Full record

ArticleFrontiers in physiology2019

Mesenchymal Stromal Cell Derived Extracellular Vesicles Reduce Hypoxia-Ischaemia Induced Perinatal Brain Injury.

Claudia Sisa, Sharad Kholia, Jordan Naylor, Maria Beatriz Herrera Sanchez, Stefania Bruno, Maria Chiara Deregibus, Giovanni Camussi, Jameel M Inal, Sigrun Lange, Mariya Hristova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Claudia SisaPerinatal Brain Protection and Repair Group, EGA Institute for Women's Health, University College London, London, United Kingdom.
Sharad KholiaDepartment of Medical Sciences, University of Turin, Turin, Italy.
Jordan NaylorPerinatal Brain Protection and Repair Group, EGA Institute for Women's Health, University College London, London, United Kingdom.
Maria Beatriz Herrera Sanchez2i3T, Incubator and Technology Transfer, Molecular Biotechnology Center, University of Turin, Turin, Italy.
Stefania BrunoDepartment of Medical Sciences, University of Turin, Turin, Italy.
Maria Chiara Deregibus2i3T, Incubator and Technology Transfer, Molecular Biotechnology Center, University of Turin, Turin, Italy.
Giovanni CamussiDepartment of Medical Sciences, University of Turin, Turin, Italy.
Jameel M InalExtracellular Vesicle Research Unit and Bioscience Research Group, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Sigrun LangeTissue Architecture and Regeneration Research Group, School of Life Sciences, University of Westminster, London, United Kingdom.
Mariya HristovaPerinatal Brain Protection and Repair Group, EGA Institute for Women's Health, University College London, London, United Kingdom.
University of Turin · ITUniversity College London · GBUniversity of Hertfordshire · GBUniversity of Westminster · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeonatal hypoxic-ischemic (HI) insult is a leading cause of disability and death in newborns, with therapeutic hypothermia being the only currently available clinical intervention. Thus there is a great need for adjunct and novel treatments for enhanced or alternative post-HI neuroprotection. Extracellular vesicles (EVs) derived from mesenchymal stromal/stem cells (MSCs) have recently been shown to exhibit regenerative effects in various injury models. Here we present findings showing neuroprotective effects of MSC-derived EVs in the Rice-Vannucci model of severe HI-induced neonatal brain insult.

methodsMesenchymal stromal/stem cell-derived EVs were applied intranasally immediately post HI-insult and behavioral outcomes were observed 48 h following MSC-EV treatment, as assessed by negative geotaxis. Brains were thereafter excised and assessed for changes in glial responses, cell death, and neuronal loss as markers of damage at 48 h post HI-insult.

resultsBrains of the MSC-EV treated group showed a significant decrease in microglial activation, cell death, and percentage tissue volume loss in multiple brain regions, compared to the control-treated groups. Furthermore, negative geotaxis test showed improved behavioral outcomes at 48 h following MSC-EV treatment.

conclusionOur findings highlight the clinical potential of using MSC-derived EVs following neonatal hypoxia-ischaemia.

Indexed as

extracellular vesicleshypoxiaischaemiamesenchymal stromal/stem cellsmicroglianeuroprotection

Identifiers

PMID30941062
PMCPMC6433879
OpenAlexW2925330721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.