Evidence map›Paper›PMID 30941021›Full record

ArticleFrontiers in behavioral neuroscience2019

Hippocampus, Amygdala, and Thalamus Volumes in Very Preterm Children at 8 Years: Neonatal Pain and Genetic Variation.

Cecil M Y Chau, Manon Ranger, Mark Bichin, Min Tae M Park, Robert S C Amaral, Mallar Chakravarty, Kenneth Poskitt, Anne R Synnes, Steven P Miller, Ruth E Grunau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Venepuncture versus heel lance for blood sampling in term neonates.The Cochrane database of systematic reviews · 2026
    Pooled it
  2. Sucrose analgesia for venepuncture in neonates.The Cochrane database of systematic reviews · 2026
    Pooled it
  3. Midazolam for sedation of infants in the neonatal intensive care unit.The Cochrane database of systematic reviews · 2025
    Pooled it
  4. Non-pharmacological management of infant and young child procedural pain.The Cochrane database of systematic reviews · 2023
    Pooled it
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cecil M Y ChauDepartment of Pediatrics, The University of British Columbia, Vancouver, BC, Canada.
Manon RangerBC Children's Hospital Research Institute, Vancouver, BC, Canada.
Mark BichinDepartment of Pediatrics, The University of British Columbia, Vancouver, BC, Canada.
Min Tae M ParkDepartment of Psychiatry, The University of Western Ontario, London, ON, Canada.
Robert S C AmaralCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, QC, Canada.
Mallar ChakravartyCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, QC, Canada.
Kenneth PoskittDepartment of Pediatrics, The University of British Columbia, Vancouver, BC, Canada.
Anne R SynnesDepartment of Pediatrics, The University of British Columbia, Vancouver, BC, Canada.
Steven P MillerDepartment of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Ruth E GrunauDepartment of Pediatrics, The University of British Columbia, Vancouver, BC, Canada.

Funding

PAIN IN PRETERM INFANTS--DEVELOPMENT AND EFFECTSR01HD039783 · NICHD · UNIVERSITY OF BRITISH COLUMBIA · PI GRUNAU, RUTH E · 2001 to 2012
$1.8M
NICHD NIH HHS R01 HD039783
6 · The paper itself

Abstract

Altered hippocampal morphology and reduced volumes have been found in children born preterm compared to full-term. Stress inhibits neurogenesis in the hippocampus, and neonatal stress/noxious stimulation in rodent pups are associated with long-term alterations in hippocampal volumes. We have previously shown reduced cortical thickness and cerebellar volumes in relation to more exposure to pain-related stress of neonatal invasive procedures in children born very preterm. We have reported targeted gene-by-pain environment interactions that contribute to long-term brain development and outcomes in this population. We now aim to determine whether exposure to pain-related stress (adjusted for clinical factors and genotype) differentially impacts regional structures within the limbic system and thalamus, and investigate relationships with outcomes in very preterm children. Our study included 57 children born very preterm (<32 weeks GA) followed longitudinally from birth who underwent 3-D T1 MRI neuroimaging at ∼8 years. Hippocampal subfields and white matter tracts, thalamus and amygdala were automatically segmented using the MAGeT Brain algorithm. The relationship between those subcortical brain volumes (adjusted for total brain volume) and neonatal invasive procedures, gestational age (GA), illness severity, postnatal infection, days of mechanical ventilation, number of surgeries, morphine exposure, and genotype (

Indexed as

amygdalageneshippocampuslimbicpainpretermstressthalamus

Identifiers

PMID30941021
PMCPMC6433974

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.