Evidence map›Paper›PMID 30941011›Full record

ArticleFrontiers in neuroscience2019

Cholinergic Signaling Alters Stress-Induced Sensitization of Hippocampal Contextual Learning.

Sarah Hersman, Ann N Hoffman, Liliann Hodgins, Shannon Shieh, Jamie Lam, Ashen Parikh, Michael S Fanselow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah HersmanDepartments of Psychology, Neurobiology, Psychiatry and Biobehavioral Sciences, and Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, CA, United States.
Ann N HoffmanDepartments of Psychology, Neurobiology, Psychiatry and Biobehavioral Sciences, and Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, CA, United States.
Liliann HodginsDepartments of Psychology, Neurobiology, Psychiatry and Biobehavioral Sciences, and Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, CA, United States.
Shannon ShiehDepartments of Psychology, Neurobiology, Psychiatry and Biobehavioral Sciences, and Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, CA, United States.
Jamie LamDepartments of Psychology, Neurobiology, Psychiatry and Biobehavioral Sciences, and Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, CA, United States.
Ashen ParikhDepartments of Psychology, Neurobiology, Psychiatry and Biobehavioral Sciences, and Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, CA, United States.
Michael S FanselowDepartments of Psychology, Neurobiology, Psychiatry and Biobehavioral Sciences, and Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, CA, United States.

Funding

Training Program in Neural MicrocircuitsT32NS058280 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2007 to 2017
$2.4M
NINDS NIH HHS T32 NS058280
6 · The paper itself

Abstract

Post-traumatic stress disorder (PTSD) has a profound contextual component, and has been demonstrated to alter future contextual learning. However, the mechanism by which a single traumatic event affects subsequent contextual experiences has not been isolated. Acetylcholine (ACh) is an important modulator of hippocampus-dependent learning such as contextual memory strength. Using Stress-Enhanced Fear Learning (SEFL), which models aspects of PTSD in rats, we tested whether muscarinic acetylcholine receptors (mAChR) in dorsal hippocampus (DH) are required during trauma for the effect of trauma on subsequent contextual fear learning. We infused scopolamine or vehicle into DH immediately before stress, and tested fear in both the trauma context and a novel context after a mild stressor. The results show that during learning, ACh acting on mAChR within the DH is required for sensitization of future contextual fear learning. However, this effect is selective for contextual learning, as this blockade leaves discrete cue sensitization intact. Rather than simply sensitizing the BLA, as previous studies have suggested, SEFL requires cholinergic signaling in DH for contextual sensitization.

Indexed as

acetylcholineamygdalafear learninghippocampusscopolaminesensitizationstress-enhanced fear learning

Identifiers

PMID30941011
PMCPMC6433822

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.