ArticleFrontiers in neuroscience2019
Altered Spatial and Temporal Brain Connectivity in the Salience Network of Sensorineural Hearing Loss and Tinnitus.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 41 citations in OpenAlex.
- Whole-Brain Structural Connectivity Alterations in Chronic Subjective Tinnitus: An Exploratory Diffusion Tensor Imaging Study.Brain sciences · 2026Article
- Cerebral blood flow alterations in non-auditory tinnitus: implications for cerebral venous congestion pathophysiology.Brain imaging and behavior · 2026Article
- Distinct neurologic state in patients with traumatic brain injury and hemorrhagic stroke during the stage of acute disorders of consciousness and the correlation with the neurological prognosis: A multi-modal PET/rs-fMRI study.NeuroImage. Clinical · 2026Article
- Age-Related Hearing Decline and Resting-State Networks.American journal of audiology · 2025Article
- Prevalence and associated factors of depression and anxiety among patients with melasma: a cross-sectional study in China.Frontiers in psychiatry · 2025Article
- Cerebral cortex functional reorganization in preschool children with congenital sensorineural hearing loss: a resting-state fMRI study.Frontiers in neurology · 2024Article
- [Progress in neural network mechanism of tinnitus using functional magnetic resonance imaging].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Article
- Association of Hearing Loss With Anatomical and Functional Connectivity in Patients With Mild Cognitive Impairment.JAMA otolaryngology-- head & neck surgery · 2023Article
- Routine Hearing Assessments in Midlife to Detect Future Dementia.JAMA otolaryngology-- head & neck surgery · 2023Article
- [Electroencephalographic microstates in vestibular schwannoma patients with tinnitus].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Functional and anatomical alterations in bilateral vestibulopathy: A multimodal neuroimaging study and clinical correlation.Frontiers in neurology · 2023Article
- Altered resting-state functional connectivity of the anterior cingulate cortex in rats post noise exposure.CNS neuroscience & therapeutics · 2022Article
- Intrinsic Network Changes in Bilateral Tinnitus Patients with Cognitive Impairment: A Resting-State Functional MRI Study.Brain sciences · 2022Article
- Tinnitus and the Triple Network Model: A Perspective.Clinical and experimental otorhinolaryngology · 2022Review
- Coupling of spatial and directional functional network connectivity reveals a physiological basis for salience network hubs in asthma.Brain imaging and behavior · 2022Article
- Dysfunction in the Interaction of Information Between and Within the Bilateral Primary Sensory Cortex.Frontiers in aging neuroscience · 2022Article
- Aberrant Functional Network of Small-World in Sudden Sensorineural Hearing Loss With Tinnitus.Frontiers in neuroscience · 2022Article
- Identifying and revealing different brain neural activities of cognitive subtypes in early course schizophrenia.Frontiers in molecular neuroscience · 2022Article
- Neuropsychological profile of hearing-impaired patients and the effect of hearing aid on cognitive functions: an exploratory study.Scientific reports · 2021Article
- Outcomes at 6 months are related to brain structural and white matter microstructural reorganization in idiopathic tinnitus patients treated with sound therapy.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensorineural hearing loss (SNHL), sometimes accompanied with tinnitus, is associated with dysfunctions within and outside the classical auditory pathway. The salience network, which is anchored in bilateral anterior insula and dorsal anterior cingulate cortex, has been implicated in sensory integration. Partial auditory deprivation could alter the characteristics of the salience network and other related brain areas, thereby contributing to hearing impairments-induced neuropsychiatric symptoms. To test this hypothesis, we performed fMRI scanning and neuropsychological tests on 32 subjects with long-term bilateral hearing impairment and 30 well-matched Controls. Non-directional functional connectivity and directional Granger causality analysis were used to identify aberrant spatial and temporal patterns of connections targeting bilateral anterior insula and dorsal anterior cingulate cortex. We found that the left anterior insula showed decreased connectivity with right precentral gyrus and superior frontal gyrus. The connections between the dorsal anterior cingulate cortex and middle frontal gyrus, superior parietal gyrus and supplementary motor area (SMA) were also reduced. Relative to Controls, SNHL patients showed abnormal effective connectivity of the salience network, including inferior temporal gyrus, cerebellum lobule VI, lobule VIII, precentral gyrus, middle frontal gyrus and SMA. Furthermore, correlation analysis demonstrated that some of these atypical connectivity measures were correlated with performance of neuropsychiatric tests. These findings suggest that the inefficient modulation of the salience network might contribute to the neural basis of SNHL and tinnitus, as well as associated cognition and emotion deficits.
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