ArticleJournal of perinatology : official journal of the California Perinatal Association2019
Premedication with neuromuscular blockade and sedation during neonatal intubation is associated with fewer adverse events.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2025.Neonatology · 2026Guideline
- Effect of neuromuscular blocking agents on tracheal intubation quality in paediatric patients: a systematic review using network meta-analysis and meta-regression.British journal of anaesthesia · 2025Pooled it
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update.Neonatology · 2023Guideline
- Association of atropine use during neonatal intubation with cardiac arrest, severe bradycardia, and other adverse events: a report from NEAR4NEOS.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Reducing tracheal intubation adverse events and severe desaturations by increasing intubation premedication use in infants <1500 g: a quality improvement initiative.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Error Traps in Pediatric Neuromuscular Block.Paediatric anaesthesia · 2026Review
- Improving LISA Practice: An Ongoing Observational Quality Improvement Initiative Following Initiation of Less-Invasive Surfactant Administration in a Level IV NICU.Children (Basel, Switzerland) · 2026Article
- Analysis of neuromuscular blockade use and prognosis in resuscitation of isolated congenital diaphragmatic hernia: data from Japanese CDH Study Group.Pediatric surgery international · 2026Article
- Pharmacological therapy of neonatal analgosedation: current status, dilemmas, and perspectives.Frontiers in pediatrics · 2026Review
- Success and safety of neonatal endotracheal tube exchanges: a NEAR4NEOS multicentre retrospective cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2025Observational
- Neonatal Tracheal Intubation in the NICU: A Literature Review.Healthcare (Basel, Switzerland) · 2025Review
- Continuous improvement of non-emergent neonatal intubations in a level IV NICU.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study.Paediatric drugs · 2025Article
- Factors that impact second attempt success for neonatal intubation following first attempt failure: a report from the National Emergency Airway Registry for Neonates.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- Current Practices and Safety of Medication Use During Pediatric Rapid Sequence Intubation.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Success rates and adverse events during neonatal intubation: Lessons learned from an international registry.Seminars in fetal & neonatal medicine · 2023Review
- Association of full premedication on tracheal intubation outcomes in the neonatal intensive care unit: an observational cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2023Observational
- Complicated Intubations are Associated with Bronchopulmonary Dysplasia in Very Low Birth Weight Infants.American journal of perinatology · 2023Article
- Sedation Prior to Intubation at Birth in Infants with Congenital Diaphragmatic Hernia: An International Survey on Current Practices.Neonatology · 2023Article
- Premedication before laryngoscopy in neonates: Evidence-based statement from the French society of neonatology (SFN).Frontiers in pediatrics · 2022Review
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 3 countries.
Funding
Abstract
objectiveTo determine the impact of premedication for tracheal intubation (TI) on adverse TI associated events, severe oxygen desaturations, and first attempt success STUDY
designRetrospective cohort study in neonatal intensive care units (NICU) participating in the National Emergency Airway Registry for Neonates from 10/2014 to 6/2017. Premedication for TI was categorized as sedation with neuromuscular blockade, sedation only, or no medication.
results2260 TIs were reported from 11 NICUs. Adverse TI associated events occurred less often in sedation with neuromuscular blockade group (10%) as compared to sedation only (29%), or no medication group (23%), p < 0.001. The adjusted odds ratio (aOR) for adverse TI associated events were: sedation with neuromuscular blockade aOR 0.48 (95%CI 0.34-0.65, p < 0.001) compared to no medication.
conclusionUse of sedation with neuromuscular blockade was associated with favorable TI outcomes. This study supports the recommendation for the standard use of sedation with neuromuscular blockade in non-emergency TIs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.