Evidence map›Paper›PMID 30940910›Full record

ArticleThe Journal of antibiotics2019

Design, synthesis, and antibacterial evaluation of novel derivatives of NPS-2143 for the treatment of methicillin-resistant S. aureus (MRSA) infection.

Yao Chen, Yuan Ju, Chungen Li, Tao Yang, Yong Deng, Youfu Luo

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Small Molecule Compounds, A Novel Strategy againstPathogens (Basel, Switzerland) · 2021
    Review
  3. Article
  4. A small molecule II-6s inhibitsJournal of oral microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yao ChenDepartment of Medicinal Chemistry, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, 610041, Chengdu, China.
Yuan JuCancer Center, West China Hospital, Sichuan University, 610041, Chengdu, China.
Chungen LiCancer Center, West China Hospital, Sichuan University, 610041, Chengdu, China.
Tao YangCancer Center, West China Hospital, Sichuan University, 610041, Chengdu, China.
Yong DengDepartment of Medicinal Chemistry, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, 610041, Chengdu, China. dengyong@scu.edu.cn.
Youfu LuoCancer Center, West China Hospital, Sichuan University, 610041, Chengdu, China. luo_youfu@scu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) infections are a significant global health challenge due to the emergence of strains exhibiting resistance to nearly all classes of antibiotics. This necessitates the rapid development of novel antimicrobials to circumvent this critical problem. Screening of compounds based on phenotypes is one of the major strategies for finding new antibiotics at present. Hence, we here performed a phenotypic screening against MRSA and identified NPS-2143 exhibiting activity against MRSA with an MIC value of 16 μg ml

Indexed as

Anti-Bacterial AgentsDrug DesignHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsNaphthalenesStaphylococcal InfectionsStructure-Activity RelationshipAnti-Bacterial AgentsNaphthalenes

Identifiers

PMID30940910

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.