Evidence map›Paper›PMID 30940878›Full record

ArticleScientific reports2019

Antibacterial Activity of combinatorial treatments composed of transition-metal/antibiotics against Mycobacterium tuberculosis.

L Z Montelongo-Peralta, A León-Buitimea, J P Palma-Nicolás, J Gonzalez-Christen, J R Morones-Ramírez

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. International journal of nanomedicine · 2026
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  14. Aminoglycoside 6'-Antibiotics (Basel, Switzerland) · 2020
    Article
  15. Silver Nanoparticles for the Therapy of Tuberculosis.International journal of nanomedicine · 2020
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

L Z Montelongo-PeraltaUniversidad Autónoma de Nuevo León, UANL. Facultad de Ciencias Químicas. Av. Universidad s/n. CD. Universitaria, 66455, San Nicolás de los Garza, NL, Mexico.
A León-BuitimeaUniversidad Autónoma de Nuevo León, UANL. Facultad de Ciencias Químicas. Av. Universidad s/n. CD. Universitaria, 66455, San Nicolás de los Garza, NL, Mexico.ORCID http://orcid.org/0000-0002-5686-4639
J P Palma-NicolásCentro Regional de Control de Enfermedades Infecciosas, Facultad de Medicina, Universidad Autónoma de Nuevo León, UANL. Av. Madero and Dr. Aguirre Pequeño s/n, Mitras centro, 64460, Monterrey, Nuevo León, Mexico.ORCID http://orcid.org/0000-0003-3508-9941
J Gonzalez-ChristenLaboratorio de Inmunidad Innata. Facultad de Farmacia. Universidad Autónoma del Estado de Morelos. Av. Universidad 1001, Col. Chamilpa, 62209, Cuernavaca, Morelos, Mexico.
J R Morones-RamírezUniversidad Autónoma de Nuevo León, UANL. Facultad de Ciencias Químicas. Av. Universidad s/n. CD. Universitaria, 66455, San Nicolás de los Garza, NL, Mexico. jose.moronesrmr@uanl.edu.mx.
Universidad Autónoma de Nuevo León · MXUniversidad Autónoma del Estado de Morelos · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Notwithstanding evidence that tuberculosis (TB) is declining, one of the greatest concerns to public health is the emergence and spread of multi-drug resistant strains of Mycobacterium tuberculosis (MDR-TB). MDR-TB are defined as strains which are resistant to at least isoniazid (INH) and rifampicin, the two most potent TB drugs, and their increasing incidence is a serious concern. Recently, notable efforts have been spent on research to pursue novel treatments against MDR-TB, especially on synergistic drug combinations as they have the potential to improve TB treatment. Our research group has previously reported promising synergistic antimicrobial effects between transition-metal compounds and antibiotics in Gram-negative and Gram-positive bacteria. In this work, we evaluated antimycobacterial activity of transition-metals/antibiotics combinatorial treatments against first-line drug resistant strains of Mycobacterium tuberculosis. Our data showed that INH/AgNO

Indexed as

A549 CellsAnimalsAntitubercular AgentsCell ProliferationCell SurvivalDrug Resistance, Multiple, BacterialDrug SynergismHumansIsoniazidMiceMicrobial Sensitivity TestsMycobacterium tuberculosisRAW 264.7 CellsSilver NitrateToxicity TestsAntitubercular AgentsIsoniazidSilver Nitrate

Identifiers

PMID30940878
PMCPMC6445279
OpenAlexW2934791552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.