ArticleScientific reports2019
Transcriptomic Diversification of Granulosa Cells during Follicular Development in Chicken.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 73 citations in OpenAlex.
- Integrative single-cell and multi-omic analysis resolves granulosa-cell programs during chicken follicle selection.Poultry science · 2026Article
- Effects of replacing extruded soybean meal with Periplaneta americana residue on laying performance, egg quality, and ovarian transcriptomic profiles in Guangxi Yao chickens.Poultry science · 2026Article
- Multi-Stage transcriptomic dissection identifies key molecular determinants of chicken follicular development.Poultry science · 2026Article
- Characterization of novel lncRNA adrenal expression profiles in response to heat stress in rats.Functional & integrative genomics · 2026Article
- Sleep deprivation impairs follicular development attributable to granulosa cell pyroptosis mediated by S100A8/A9-driven macrophage M1 polarization.Science advances · 2026Article
- Metabolomics and Lipidomics in the Study of Reproductive Performance in Livestock.Animals : an open access journal from MDPI · 2026Review
- ceRNA regulatory networks reveals gga-miR-30b-5p as a regulator of granulosa cell apoptosis via targeting NR5A2 in atrophic ovaries of broody chickens.Poultry science · 2026Article
- Dietary supplementation with 25-hydroxycholecalciferol is more effective than cholecalciferol in improving reproductive performance in aged duck breeders.Journal of animal science · 2026Article
- Integrative Transcriptome Analysis Across Follicles Highlights Key Regulatory Pathways in Low and High-Egg-Laying Hens.Animals : an open access journal from MDPI · 2025Article
- The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome.Endocrine connections · 2025Review
- Changes in Ovarian Activity and Expressions of Follicle Development Regulation Factors During the Laying-Incubation Cycle in Magang Geese.Animals : an open access journal from MDPI · 2025Article
- Regulatory Mechanism ofBiomolecules · 2025Article
- Variants inVeterinary sciences · 2025Article
- Regulatory signatures involved in the cell cycle pathway contribute to egg production heterosis in chicken.Journal of animal science and biotechnology · 2025Article
- The Impact of Dietary Encapsulated Fennel Seed (Foeniculum vulgare Mill.) Essential Oil Inclusion Levels on Performance, Serum Hormone Profiles, and Expression of Reproductive Axis-Related Genes in the Early and Late Laying Phases of Hens.Veterinary medicine and science · 2025Article
- miR-383 regulates sheep granular cell proliferation and apoptosis by targetingArchives animal breeding · 2025Article
- Molecular profiling of signaling pathways involved in chicken ovarian follicle development by transcriptome sequencing.Frontiers in veterinary science · 2025Article
- Proteome of granulosa cells lipid droplets reveals mechanisms regulating lipid metabolism at hierarchical and pre-hierarchical follicle in goose.Frontiers in veterinary science · 2025Article
- Cross-species regulatory network analysis identifies FOXO1 as a driver of ovarian follicular recruitment.Scientific reports · 2024Article
- Clinical significance and biological roles of lncRNA CTBP1-AS in polycystic ovary syndrome.Journal of ovarian research · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Granulosa cells play important roles in ovarian follicular development. To better understand the molecular mechanisms involved in this physiological process in chicken, high-throughput transcriptome analyses were performed to study the expression profiles of granulosa cells harvested from 6 mm white follicles, F5 follicles and F1 follicles. The analyses elucidated a clear tendency of granulosa cells in shifting its expression profile from proliferation to differentiation during follicular development. Transcripts down-regulated during this process were mainly associated with cell division, cell cycle and DNA replication while the up-regulated transcripts were related to ribosomal function, lipid metabolism and protein synthesis. Our study for the first time provides the complete gene expression profiles along follicular development supporting the active involvement of many genes characterized in cell signaling (AMH, Inhibins, Activins, BMPs) and transcription factors (SMAD3, SMAD5, ID1, ID2, ID3). Their temporal expression profiles support the notion of continual cross-talk between granulosa cells and its neighboring cells and shed light on the mechanisms behind avian follicular selection and pave the way to the better understanding of reproductive efficiency.
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