Evidence map›Paper›PMID 30940839›Full record

ArticleScientific reports2019

Environmental interactions are regulated by temperature in Burkholderia seminalis TC3.4.2R3.

Priscila Jane Romano de Oliveira Gonçalves, Carmen C Denman Hume, Almir José Ferreira, Sarina Tsui, Marcelo Brocchi, Brendan W Wren, Welington Luiz Araujo

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Evaluation of CHROMagar™ B. cepacia agar for the detection of Burkholderia cepacia complex species from sputum samples of patients with cystic fibrosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Priscila Jane Romano de Oliveira GonçalvesUniversity of São Paulo, Department of Microbiology, São Paulo, 05508-900, Brazil.
Carmen C Denman HumeLondon School of Hygiene and Tropical Medicine, Department of Pathogen Molecular Biology, London, WC1E 7HT, United Kingdom.ORCID http://orcid.org/0000-0001-9112-9923
Almir José FerreiraUniversity of São Paulo, Department of Microbiology, São Paulo, 05508-900, Brazil.
Sarina TsuiUniversity of São Paulo, Department of Microbiology, São Paulo, 05508-900, Brazil.
Marcelo BrocchiUniversity of Campinas, Department of Genetics, Evolution, Microbiology and Immunology, São Paulo, 13083-862, Brazil.ORCID http://orcid.org/0000-0002-3020-531X
Brendan W WrenLondon School of Hygiene and Tropical Medicine, Department of Pathogen Molecular Biology, London, WC1E 7HT, United Kingdom.ORCID http://orcid.org/0000-0002-6140-9489
Welington Luiz AraujoUniversity of São Paulo, Department of Microbiology, São Paulo, 05508-900, Brazil. wlaraujo@usp.br.

Funding

Wellcome Trust 102979/Z/13/Z
6 · The paper itself

Abstract

Burkholderia seminalis strain TC3.4.2R3 is an endophytic bacterium isolated from sugarcane roots that produces antimicrobial compounds, facilitating its ability to act as a biocontrol agent against phytopathogenic bacteria. In this study, we investigated the thermoregulation of B. seminalis TC3.4.2R3 at 28 °C (environmental stimulus) and 37 °C (host-associated stimulus) at the transcriptional and phenotypic levels. The production of biofilms and exopolysaccharides such as capsular polysaccharides and the biocontrol of phytopathogenic fungi were enhanced at 28 °C. At 37 °C, several metabolic pathways were activated, particularly those implicated in energy production, stress responses and the biosynthesis of transporters. Motility, growth and virulence in the Galleria mellonella larvae infection model were more significant at 37 °C. Our data suggest that the regulation of capsule expression could be important in virulence against G. mellonella larvae at 37 °C. In contrast, B. seminalis TC3.4.2R3 failed to cause death in infected BALB/c mice, even at an infective dose of 10

Indexed as

Adaptation, PhysiologicalAnimalsBacterial ProteinsBiofilmsBody Temperature RegulationBurkholderiaGene Expression ProfilingGene Expression Regulation, BacterialLarvaMiceMothsPhenotypePolysaccharides, BacterialTemperatureBacterial ProteinsPolysaccharides, Bacterial

Identifiers

PMID30940839
PMCPMC6445077

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.