ArticleNature communications2019
Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 2 pooled it
12.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
111 citing papers in PubMed, 2 syntheses or guidelines pooled it, 223 citations in OpenAlex.
- Reproducible and opposing gut microbiome signatures distinguish autoimmune diseases and cancers: a systematic review and meta-analysis.Microbiome · 2022Pooled it
- Diet, Microbes, and Cancer Across the Tree of Life: a Systematic Review.Current nutrition reports · 2022Pooled it
- Molecular pathways linking the gut microbiome to antitumor immunity.Trends in microbiology · 2026Review
- RNF5 promotes acute lung injury through HSPA5 ER-to-cytosol translocation and resultant PERK activation.Cell death and differentiation · 2026Article
- Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity and limits melanoma growth.Cell reports. Medicine · 2026Article
- Gut microbiota and immune modulation: role in neurodegenerative disorders and cancer.Molecular biology reports · 2026Review
- Endoplasmic reticulum stress in antitumor immunity and immunotherapy resistance: mechanisms and therapeutic implications.Molecular cancer · 2026Review
- Microbiota-induced EI24 improves homeostasis but impedes function of alveolar macrophages via metabolic regulation.Nature communications · 2026Article
- The role of ER-associated degradation and ER-phagy in health and disease.Signal transduction and targeted therapy · 2026Review
- TMEM33 deletion potentiates anti-tumor CD8bioRxiv : the preprint server for biology · 2026Article
- Faecalibaculum rodentium Alleviates Ionizing Radiation-Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The gut-skin axis in melanoma: from microbial regulatory mechanisms to clinical translation for precision management.Frontiers in microbiology · 2026Review
- Exploring the Gut Microbiota as a Promising Target for Breast Cancer Treatment.Current molecular medicine · 2026Review
- A bittersweet symphony: soluble mediator networks orchestrate melanoma plasticity and therapeutic adaptation.Frontiers in cell and developmental biology · 2026Review
- Targeting the unfolded protein response for cancer therapy: mitigating tumor adaptation and immune suppression.Biomarker research · 2025Review
- Article
- Gut microbiome and nutritional strategies in gastrointestinal cancers: Clinical implications and therapeutic perspectives.World journal of clinical oncology · 2025Review
- Associations Between the Gut Microbiome and Outcomes in Autologous Stem Cell Transplantation: A Systematic Review.Microorganisms · 2025Review
- Review
- Clinical Evidence for Microbiome-Based Strategies in Cancer Immunotherapy: A State-of-the-Art Review.Medicina (Kaunas, Lithuania) · 2025Review
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors at 14 institutions in 4 countries.
Yan LiSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Roberto TinocoSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Lisa ElménSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Igor SegotaSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Yibo XianDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Yu FujitaSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0002-8916-7303
Avinash SahuCenter for Bioinformatics and Computational Biology, Department of Computer Science, University of Maryland, College Park, MD, 20742, USA.
Raphy ZareckiSchool of Computer Sciences and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Kerrie MarieLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Yongmei FengSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Ali KhatebTechnion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, 31096, Israel.
Dennie T FrederickDivision of Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Shiri K AshkenaziTechnion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, 31096, Israel.
Hyungsoo KimSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0002-8189-5939
Eva Guijarro PerezLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Chi-Ping DayLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Rafael S Segura MuñozDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Robert SchmaltzDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Shibu YoosephDepartment of Computer Science, College of Engineering and Computer Science, University of Central Florida, Orlando, FL, 32816, USA.
Miguel A TamBioLegend, San Diego, CA, 92121, USA.
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, Bethesda, MD, 20892, USA.
Emily Avitan-HershTechnion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, 31096, Israel.
Lihi TzurDepartments of Dermatology and Oncology, Rambam Health Care Campus, Technion Faculty of Medicine, Haifa, 31096, Israel.
Shoshana RoizmanDepartments of Dermatology and Oncology, Rambam Health Care Campus, Technion Faculty of Medicine, Haifa, 31096, Israel.
Ilanit BoyangoDepartments of Dermatology and Oncology, Rambam Health Care Campus, Technion Faculty of Medicine, Haifa, 31096, Israel.
Gil Bar-SelaTechnion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, 31096, Israel.
Amir OrianTechnion Integrated Cancer Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, 31096, Israel.
Randal J KaufmanSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0003-4277-316X
Marcus BosenbergDepartment of Pathology, Yale University, New Haven, CT, USA.
Colin R GodingLudwig Institute for Cancer Research, Nuffield Department of Medicine, Old Road Campus, Unviversity of Oxford, Headington, Oxford, OX3 7DQ, UK.ORCID http://orcid.org/0000-0002-1614-3909
Bas BaatenSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Mitchell P LevesqueDepartment of Dermatology, University Hospital of Zurich and University of Zurich, 8091, Zurich, Switzerland.
Reinhard DummerDepartment of Dermatology, University Hospital of Zurich and University of Zurich, 8091, Zurich, Switzerland.
Kevin BrownDivision of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-8558-6711
Glenn MerlinoLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Eytan RuppinCenter for Bioinformatics and Computational Biology, Department of Computer Science, University of Maryland, College Park, MD, 20742, USA.
Keith FlahertyDivision of Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0002-3402-0478
Amanda Ramer-TaitDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.ORCID http://orcid.org/0000-0003-0950-7548
Tao LongSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0002-7052-9546
Scott N PetersonSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Linda M BradleySanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Ze'ev A RonaiSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA. zeev@ronailab.net.
Sanford Burnham Prebys Medical Discovery Institute · USTechnion – Israel Institute of Technology · ILNational Institutes of Health · USUniversity of Nebraska–Lincoln · USRambam Health Care Campus · ILHarvard University · USNational Cancer Institute · USUniversity of Zurich · CHBioLegend (United States) · USLudwig Cancer Research · GBTel Aviv University · ILUniversity of Central Florida · USUniversity of Maryland, College Park · USYale University · US
Funding
Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2MTumor Assessment CoreP01CA128814 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SMITH, JEFFREY W · 2009 to 2020
$19.1MPreclinical Mouse Models for Studying Immune Checkpoint Inhibitor ResponseZIABC011167 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MERLINO, GLENN T. · 2009 to 2024
$12.4MRewired Signaling at the Nexus of Melanoma Metastasis and ResistanceR35CA197465 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI RONAI, ZEEV A. · 2016 to 2022
$7.9MER stress and UPR in non-alcoholic steatohepatitis and hepatocellular carcinomaR01CA198103 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2016 to 2020
$3.4MLinking the microbiome and immune-checkpoint in melanoma by RNF5R01CA216187 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI BRADLEY, LINDA MAC PHERSON · 2017 to 2021
$3.0MHomeostatic Role of IRE1a-XBP1-PDI1 in Hepatic Lipid MetabolismR01DK103185 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2015 to 2019
$2.9MMechanism of ER Protein Misfolding-Induced Mitochondrial DysfunctionR01DK113171 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2017 to 2020
$2.5MRegulation of Chronic Viral InfectionsR01AI106895 · NIAID · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI BRADLEY, LINDA MAC PHERSON · 2014 to 2017
$1.9MNCI NIH HHS P01 CA128814NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA198103NCI NIH HHS R01 CA216187NCI NIH HHS R35 CA197465NIAID NIH HHS R01 AI106895NIDDK NIH HHS R01 DK103185NIDDK NIH HHS R01 DK113171NIH HHS CA198103NIH HHS DK103185NIH HHS P30 CA030199NIH HHS R01CA216187NIH HHS R35CA197465
Abstract
Accumulating evidence points to an important role for the gut microbiome in anti-tumor immunity. Here, we show that altered intestinal microbiota contributes to anti-tumor immunity, limiting tumor expansion. Mice lacking the ubiquitin ligase RNF5 exhibit attenuated activation of the unfolded protein response (UPR) components, which coincides with increased expression of inflammasome components, recruitment and activation of dendritic cells and reduced expression of antimicrobial peptides in intestinal epithelial cells. Reduced UPR expression is also seen in murine and human melanoma tumor specimens that responded to immune checkpoint therapy. Co-housing of Rnf5
Indexed as
Cell ProliferationGastrointestinal MicrobiomeAnimalsAntimicrobial Cationic PeptidesBacteriaHumansIntestinesMelanomaMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutUbiquitin-Protein LigasesUnfolded Protein ResponseAntimicrobial Cationic PeptidesMembrane ProteinsRNF5 protein, mouseUbiquitin-Protein Ligases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.