ArticleNature communications2019
Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 226 papers.
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Who cites it
226 citing papers in PubMed.
- Towards a Standard Threshold for Genome Wide Significance in Dogs.Animal genetics · 2026Article
- Multi-omic analysis of canine aging uncovers conserved aging pathways.GeroScience · 2026Article
- Genotypic and phenotypic consequences of domestication in dogs.G3 (Bethesda, Md.) · 2026Article
- OmniExtract: an automatic data extraction tool based on large language model and prompt engineering.Briefings in bioinformatics · 2026Article
- On the ancestry and evolution of the extinct dire wolf.Cell genomics · 2026Article
- Scalable high resolution ancestry deconvolution for genomic data.Nature communications · 2026Article
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- Genome-wide variation landscape reveals temperature adaptation in Chinese indigenous cattle.Journal of animal science and biotechnology · 2026Article
- Integrative MRI and Genomics Analyses PrioritizeAnimals : an open access journal from MDPI · 2026Article
- Image feature embedding with a deep learning framework improves genome-wide association studies on dog endophenotypes.Science advances · 2026Article
- An interpretable machine learning framework for dog breed inference and ancestry decomposition.bioRxiv : the preprint server for biology · 2026Article
- Genomic insights into six dog breeds owned in India: a ddRAD sequencing approach.BMC genomics · 2026Article
- Blood biomarkers and breed genetics of aging in pet dogs.bioRxiv : the preprint server for biology · 2026Article
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- Phenome-wide study connects behavioral genetics of odor detection dogs with temperament traits.Scientific reports · 2026Article
- Genomic history of early dogs in Europe.Nature · 2026Article
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- Companion Dogs in Vietnam: Exploring Characteristics of Owned and Ideal Dogs.Animals : an open access journal from MDPI · 2026Article
- Genomic architecture of insertion-deletion (indel) variants in beetal goats of India.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- A Test of the Adaptive Lag Hypothesis of the Evolution of Cancer Suppression and Lifespan in Dog Breeds.Genes · 2026Article
166 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and breed-associated behaviors resulting from human selective pressures. To identify the genetic underpinnings of such traits, we analyze 722 canine whole genome sequences (WGS), documenting over 91 million single nucleotide and small indels, creating a large catalog of genomic variation for a companion animal species. We undertake both selective sweep analyses and genome wide association studies (GWAS) inclusive of over 144 modern breeds, 54 wild canids and a hundred village dogs. Our results identify variants of strong impact associated with 16 phenotypes, including body weight variation which, when combined with existing data, explain greater than 90% of body size variation in dogs. We thus demonstrate that GWAS and selection scans performed with WGS are powerful complementary methods for expanding the utility of companion animal systems for the study of mammalian growth and biology.
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