Evidence map›Paper›PMID 30940727›Full record

ArticleThe Journal of biological chemistry2019

High-resolution structure of RGS17 suggests a role for Ca

Monita Sieng, Michael P Hayes, Joseph B O'Brien, C Andrew Fowler, Jon C Houtman, David L Roman, Angeline M Lyon

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Monita SiengDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907.
Michael P HayesDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242.
Joseph B O'BrienDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242.
C Andrew FowlerNMR Facility, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.
Jon C HoutmanDepartment of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242.
David L RomanDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242.
Angeline M LyonDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907; Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907. Electronic address: lyonam@purdue.edu.
University of Iowa · USPurdue University West Lafayette · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
PREDOCTORAL TRAINING PROGRAM IN BIOTECHNOLOGYT32GM008365 · NIGMS · UNIVERSITY OF IOWA · PI KERNS, ROBERT JOHN · 1990 to 2021
$3.8M
Structural Studies of PLCepsilon a regulator of cardiac contractility and hypertrophy.R01HL141076 · NHLBI · PURDUE UNIVERSITY · PI Angeline Marie Lyon · 2018 to 2026
$2.5M
NHLBI NIH HHS R01 HL141076NIGMS NIH HHS T32 GM008365
6 · The paper itself

Abstract

Regulator of G protein signaling (RGS) proteins are negative regulators of G protein-coupled receptor (GPCR) signaling through their ability to act as GTPase-activating proteins (GAPs) for activated Gα subunits. Members of the RZ subfamily of RGS proteins bind to activated Gα

Indexed as

Calcium SignalingCalciumCrystallography, X-RayGTP-Binding Protein alpha SubunitsGuanosine TriphosphateHumansHydrolysisMagnesiumRGS ProteinsCalciumGTP-Binding Protein alpha SubunitsGuanosine TriphosphateMagnesiumRGS17 protein, humanRGS Proteinscalciumcell signalingcrystal structureG protein-coupled receptor (GPCR)GTPase activating protein (GAP)heterotrimeric G proteinisothermal titration calorimetry (ITC)nuclear magnetic resonance (NMR)protein crystallizationregulator of G protein signaling (RGS)RGS17RZ subfamily

Identifiers

PMID30940727
PMCPMC6527179
OpenAlexW2933693412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.