ArticleThe Journal of experimental medicine2019
Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Endocrine-Metabolic Crosstalk Between Diabetes Mellitus and Hypothyroidism: From Network Mechanisms to Translational Stratification.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Thyroid hormone sensitivity, insulin resistance and visceral fat area as determinants of prevalent coronary heart disease in euthyroid patients with type 2 diabetes.Frontiers in endocrinology · 2026Article
- TSH promotes right ventricle hypertrophy and energy metabolism remodeling in PAH mice.Endocrine connections · 2025Article
- Integrative Mendelian randomization and multi-omics analysis identifies anti-allergic drug targets associated with cardiovascular disease risk.Scientific reports · 2025Article
- TSH upregulates CYP4B1 through the PI3K/AKT/CREB pathway to promote cardiac hypertrophy.Journal of endocrinological investigation · 2025Article
- Thyrotropin exacerbates insulin resistance by triggering macrophage inflammation in subclinical hypothyroidism.Experimental & molecular medicine · 2025Article
- Article
- Thyroid-Stimulating Hormone Regulates the Glucose Metabolism in Hepatocytes via Toll-Like Receptor 4/Tollip Pathway.International journal of endocrinology · 2025Article
- Effect of thyroid stimulating hormone on the prognosis of coronary heart disease.Frontiers in endocrinology · 2025Article
- Inflammation in atherosclerosis: pathophysiology and mechanisms.Cell death & disease · 2024Review
- Increased thyroid stimulating hormone (TSH) as a possible risk factor for atherosclerosis in subclinical hypothyroidism.Thyroid research · 2024Review
- Association between rheumatoid arthritis and autoimmune thyroid disease: evidence from complementary genetic methods.Endocrine · 2024Article
- Association between atherosclerosis and the development of multi-organ pathologies.SAGE open medicine · 2024Review
- Exercise Attenuates Doxorubicin-Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR-30d-5p/GALNT7.Journal of immunology research · 2024Article
- Thyroid-stimulating hormone may participate in insulin resistance by activating toll-like receptor 4 in liver tissues of subclinical hypothyroid rats.Molecular biology reports · 2023Article
- Atypical pituitary hormone-target tissue axis.Frontiers of medicine · 2023Review
- Correlation of thyroid-related hormones with vascular complications in type 2 diabetes patients with euthyroid.Frontiers in endocrinology · 2022Article
- Characteristics of coronary artery disease in patients with subclinical hypothyroidism: evaluation using coronary artery computed tomography angiography.BMC cardiovascular disorders · 2021Article
- TAK1-AMPK Pathway in Macrophages Regulates Hypothyroid Atherosclerosis.Cardiovascular drugs and therapy · 2021Article
- TSH Combined with TSHR Aggravates Diabetic Peripheral Neuropathy by Promoting Oxidative Stress and Apoptosis in Schwann Cells.Oxidative medicine and cellular longevity · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 3 institutions in 1 country.
Chongbo YangDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.ORCID 0000-0003-2277-8473
Ming LuDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.
Wenbin ChenScientific Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Zhao HeDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.
Xu HouDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.
Mei FengScientific Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Hongjia ZhangDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Laboratory for Cardiovascular Precision Medicine, Beijing, China.
Tao BoScientific Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Xiaoming ZhouScientific Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Yong YuDepartment of Sonography, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Haiqing ZhangDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.
Meng ZhaoDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.
Laicheng WangScientific Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Chunxiao YuDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.
Ling GaoScientific Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Wenjian JiangDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Laboratory for Cardiovascular Precision Medicine, Beijing, China jjzhao@sdu.edu.cn wz.zhangqy@sdu.edu.cn.
Qunye ZhangKey Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Ministry of Public Health, the State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China wz.zhangqy@sdu.edu.cn.
Jiajun ZhaoDepartment of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China jjzhao@sdu.edu.cn.ORCID 0000-0002-8697-4791
Shandong University · CNCapital Medical University · CNQilu Hospital of Shandong University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subclinical hypothyroidism is associated with cardiovascular diseases, yet the underlying mechanism remains largely unknown. Herein, in a common population (
Indexed as
Carotid Intima-Media ThicknessAgedAnimalsAtherosclerosisCytokinesFemaleFollow-Up StudiesHumansI-kappa B ProteinsInflammationMacrophagesMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, Knockout, ApoECytokinesI-kappa B ProteinsNF-kappa BReceptors, ThyrotropinThyrotropin
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LicenceCC BY-NC-SA
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.