Evidence map›Paper›PMID 30940709›Full record

ArticlemBio2019

Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli.

Connor J Beebout, Allison R Eberly, Sabrina H Werby, Seth A Reasoner, John R Brannon, Shuvro De, Madison J Fitzgerald, Marissa M Huggins, Douglass B Clayton, Lynette Cegelski and 1 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 83 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The role ofResearch square · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. A review of the mechanisms that confer antibiotic resistance in pathotypes ofFrontiers in cellular and infection microbiology · 2024
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Connor J BeeboutDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Allison R EberlyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sabrina H WerbyDepartment of Chemistry, Stanford University, Stanford, California, USA.
Seth A ReasonerDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John R BrannonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Shuvro DeDivision of Pediatric Urology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Madison J FitzgeraldVanderbilt University, Nashville, Tennessee, USA.
Marissa M HugginsVanderbilt University, Nashville, Tennessee, USA.
Douglass B ClaytonDivision of Pediatric Urology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Lynette CegelskiDepartment of Chemistry, Stanford University, Stanford, California, USA.
Maria HadjifrangiskouDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA maria.hadjifrangiskou@vumc.org.
Vanderbilt University Medical Center · USStanford University · USVanderbilt University · US

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Two-component system interactions as uropathogenic Escherichia coli drug targetsR01AI107052 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HADJIFRANGISKOU, MARIA · 2015 to 2019
$1.9M
Mechanisms of Cellular Adaptation in CystitisK08DK106472 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAYTON, DOUGLASS BROOKS · 2015 to 2019
$713k
NIAID NIH HHS R01 AI107052NIDDK NIH HHS K08 DK106472NIDDK NIH HHS U24 DK076169NIGMS NIH HHS T32 GM007347
6 · The paper itself

Abstract

Biofilms are multicellular bacterial communities encased in a self-secreted extracellular matrix comprised of polysaccharides, proteinaceous fibers, and DNA. Organization of these components lends spatial organization to the biofilm community such that biofilm residents can benefit from the production of common goods while being protected from exogenous insults. Spatial organization is driven by the presence of chemical gradients, such as oxygen. Here we show that two quinol oxidases found in

Indexed as

Biological Variation, PopulationGenetic HeterogeneityAerobiosisAnaerobiosisBiofilmsOxidation-ReductionOxidoreductasesOxygenUropathogenic Escherichia coliduroquinol oxidaseOxidoreductasesOxygenbiofilmsEscherichia coliheterogeneityoxygen gradientsrespirationurinary tract infection

Identifiers

PMID30940709
PMCPMC6445943
OpenAlexW2952708141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.