ArticleDiabetes care2019
Heart Rate, Autonomic Function, and Future Changes in Glucose Metabolism in Individuals Without Diabetes: The Whitehall II Cohort Study.
Article in Diabetes care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals.Nutrients · 2022Trial
- Neuromodulation using Bioelectronics-enabled therapies to combat insulin resistance and its comorbidities.Journal of diabetes and metabolic disorders · 2026Review
- Effect of 4 Weeks Resonance Frequency Breathing on Glucose Metabolism and Autonomic Tone in Healthy Adults.Diabetes & metabolism journal · 2025Article
- Heart Rate Variability Analysis in Congestive Heart Failure: The Need for Standardized Assessment Protocols.Reviews in cardiovascular medicine · 2025Review
- Independent and interactive associations of heart rate and obesity with type 2 diabetes mellites: A population-based study.Journal of diabetes · 2024Article
- Heart Rate Variability and Cognition: A Narrative Systematic Review of Longitudinal Studies.Journal of clinical medicine · 2024Review
- Heart Rate Variability and Incident Type 2 Diabetes in General Population.The Journal of clinical endocrinology and metabolism · 2023Article
- Autonomic dysfunction is associated with the development of arterial stiffness: the Whitehall II cohort.GeroScience · 2023Article
- Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo-The Maastricht Study.Cardiovascular diabetology · 2023Article
- Association between initial in-hospital heart rate and glycemic control in patients with acute ischemic stroke and diabetes mellitus.BMC endocrine disorders · 2023Article
- The Association of Measures of Cardiovascular Autonomic Function, Heart Rate, and Orthostatic Hypotension With Incident Glucose Disorders: The Cardiovascular Health Study.Diabetes care · 2022Article
- Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary Atherosclerosis.Journal of the American Heart Association · 2022Article
- Determinants of Longitudinal Change of Glycated Hemoglobin in a Large Non-Diabetic Population.Journal of personalized medicine · 2021Article
- Article
- [Bivariate heritability estimation of resting heart rate and common chronic disease based on extended pedigrees].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- Associations of sleep quality, sleep apnea and autonomic function with insulin secretion and sensitivity: HSCAA study.Metabolism open · 2020Article
- Digital Resilience Biomarkers for Personalized Health Maintenance and Disease Prevention.Frontiers in digital health · 2020Review
- Sex differences in heart rate responses to postural provocations.International journal of cardiology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveAutonomic nervous system dysfunction is associated with impaired glucose metabolism, but the temporality of this association remains unclear in individuals without diabetes. We investigated the association of autonomic function with 5-year changes in glucose metabolism in individuals without diabetes. RESEARCH DESIGN AND
methodsAnalyses were based on 9,000 person-examinations for 3,631 participants without diabetes in the Whitehall II cohort. Measures of autonomic function included 5-min resting heart rate and six heart rate variability (HRV) indices. Associations between baseline autonomic function measures and 5-year changes in fasting and 2-h plasma glucose, serum insulin concentrations, insulin sensitivity (insulin sensitivity index [ISI
resultsA 10-bpm higher resting heart rate was associated with 5-year changes in fasting and 2-h insulin and ISI
conclusionsHigher resting heart rate in individuals without diabetes is associated with future unfavorable changes in insulin levels and insulin sensitivity. Associations may be mediated via autonomic function; however, results are inconclusive. Resting heart rate may be a risk marker for future pathophysiological changes in glucose metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.