Evidence map›Paper›PMID 30940478›Full record

ArticleBiological psychology2019

Socio-demographic predictors of prepulse inhibition: A prospective study in children and adolescents from Mexico City.

Kalé Z Kponee-Shovein, Rachel Grashow, Brent A Coull, Martha M Téllez-Rojo, Lourdes Schnaas, Maria Del Carmen Hernández-Chávez, Brisa Sánchez, Karen Peterson, Howard Hu, Mauricio Hernandez-Avila and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Kalé Z Kponee-ShoveinDepartments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: kak785@mail.harvard.edu.
Rachel GrashowDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Brent A CoullDepartments of Biostatistics and Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Martha M Téllez-RojoCenter for Nutrition and Health Research, National Institute of Public Health, Mexico.
Lourdes SchnaasDivision of Research in Community Interventions, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Miguel Hidalgo, Mexico.
Maria Del Carmen Hernández-ChávezDivision of Research in Community Interventions, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Miguel Hidalgo, Mexico.
Brisa SánchezDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Karen PetersonDepartments of Global Public Health and Nutritional Sciences, University of Michigan School of Public health, Ann Arbor, MI, USA.
Howard HuUniversity of Washington School of Public Health, Seattle, WA, USA.
Mauricio Hernandez-AvilaCenter for Nutrition and Health Research, National Institute of Public Health, Mexico.
Marc G WeisskopfDepartments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USInstituto Nacional de Perinatología · MXUniversity of Michigan · USUniversity of Washington · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
VANADIUM AND HUMAN HEALTHP42ES005947 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 1992 to 2006
$19.6M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
LEAD DOSE BIOMARKERS, REPRODUCTION, AND INFANT OUTCOMESR01ES007821 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, KAREN EILEEN · 1998 to 2010
$4.7M
Project 3: Developmental Exposures and Diet: Epigenetics of Metabolic SyndromeP01ES022844 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PADMANABHAN, VASANTHA, SONG, PETER XUEKUN · 2013 to 2018
$3.9M
Prenatal and Childhood Exposure to Fluoride and NeurodevelopmentR01ES021446 · NIEHS · UNIVERSITY OF TORONTO · PI HU, HOWARD, MCLAUGHLIN, JOHN · 2012 to 2018
$2.3M
NEW BIOMARKERS OF NEUROTOXICITYK01ES012653 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WEISSKOPF, MARC G · 2004 to 2008
$613k
NIEHS NIH HHS K01 ES012653NIEHS NIH HHS P01 ES022844NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P42 ES005947NIEHS NIH HHS R01 ES007821NIEHS NIH HHS R01 ES021446NIEHS NIH HHS T32 ES007069
6 · The paper itself

Abstract

Prepulse inhibition (PPI) is a sensorimotor gating mechanism that reduces interfering influences to the neural processing of incoming stimuli, and is associated with several neurodevelopmental disorders. To date, research on PPI and neurodevelopmental disorders has primarily been in cross-sectional, clinical settings. In this prospective, epidemiologic study, we used a data-driven prediction model to identify socio-demographic predictors of PPI in children and adolescents from Mexico City to inform future etiologic studies evaluating PPI. We conducted variable selection and validation using a modified version of the multiple imputation random lasso (MIRL) variable selection algorithm. MIRL identified six predictors of PPI at a stimulus onset asynchrony of 120 ms or 240 ms. Of those six predictors, maternal education, birthweight, and total breastfeeding months were highlighted as previously unstudied variables associated with enhanced PPI. Our findings highlight the potential value of PPI as an adjunct screening tool for identifying children at risk for neurodevelopmental disorders and underscore the relevance for validation research on this topic.

Indexed as

Prepulse InhibitionAdolescentAlgorithmsChildDemographyFemaleHumansMaleMexicoNeurodevelopmental DisordersProspective StudiesRisk AssessmentRisk FactorsSensory GatingHuman startle reflexNeurodevelopmental disordersPrepulse inhibitionRisk factorsSensorimotor gating

Identifiers

PMID30940478
PMCPMC12042598
OpenAlexW2925492161

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.